The effect on bile flow of two different doses of furosemide (4 and 40 mg/kg b.w.) was studied in rats with normal or suppressed renal function. A prompt and significant increase of the canalicular bile flow was observed in rats with normal renal function after 40 mg/kg i.v., whereas a significant decrease was evident after the lower dose. The differences in canalicular bile flow could be referred to changes of the bile salt independent canalicular fraction, since no variation in bile salt excretion rate and in bile to plasma ratio of 14C-erythritol was seen after treatment with either of the doses. Renal pedicle ligature abolished the decrease of canalicular bile flow exerted by administration of the lower dose. These apparently paradoxical results may be explained by the inhibition of active sodium transport with the lower of the two doses employed. Larger doses of the drug or the increase of its biliary excretion after suppression of renal function may lead to choleresis through an osmotic effect.
|Number of pages||5|
|Journal||Italian Journal of Gastroenterology|
|Publication status||Published - 1978|
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