Cholestasis Induced by Total Parenteral Nutrition

Francesco William Guglielmi, Nunzia Regano, Silvia Mazzuoli, Simona Fregnan, Giuseppina Leogrande, Altomarino Guglielmi, Manuela Merli, Loris Pironi, J. M M Penco, Antonio Francavilla

Research output: Contribution to journalArticlepeer-review


Parenteral nutrition is a life-saving treatment for patients who have acute and chronic intestinal failure. Severe cholestasis induced by total parental nutrition (TPN-IC) is characterized by bile duct regeneration, portal inflammation, and fibrosis. Its progression could be very rapid, and in some patients liver cirrhosis may develop in few months. This article describes the definition, incidence, hepatic changes, histopathologic findings, risk factors, pathogenesis, and clinical implications of TPN-IC. The goal is to improve hospital and home management, quality of life, and prognosis of patients requiring parenteral nutrition.

Original languageEnglish
Pages (from-to)97-110
Number of pages14
JournalClinics in Liver Disease
Issue number1
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Hepatology


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