Cholesterol-adjusted vitamin e serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation

Roberto Cangemi, Pasquale Pignatelli, Roberto Carnevale, Gino Roberto Corazza, Daniele Pastori, Alessio Farcomeni, Stefania Basili, Giovanni Davì, Domenico Ferro, William R. Hiatt, Giuseppe Licata, Gregory Y H Lip, Lorenzo Loffredo, Pier Mannuccio Mannucci, Annarita Vestri, Francesco Violi

Research output: Contribution to journalArticlepeer-review

Abstract

Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation. Methods Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0 months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded. Results During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8 ± 1.2 vs. 4.4 ± 1.8 μmol/mmol cholesterol; p <0.001). Using a Cox proportional hazard model, age, diabetes, history of stroke and myocardial infarction and vitamin E serum levels (HR 0.77; 95% CI: 0.67-0.89; p = 0.001) independently predicted cardiovascular events. Patients with vitamin E <4.2 μmol/mmol cholesterol (median values) had an increased risk of cardiovascular events (HR 1.87; 95% CI: 1.25-2.80: p = 0.002). Conclusions Low vitamin E serum levels are associated with an increased risk of cardiovascular events in patients with non-valvular atrial fibrillation.

Original languageEnglish
Pages (from-to)3241-3247
Number of pages7
JournalInternational Journal of Cardiology
Volume168
Issue number4
DOIs
Publication statusPublished - Oct 9 2013

Keywords

  • Atrial fibrillation
  • Cardiovascular events
  • Vitamin E

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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