Cholesterol distribution between HDL subfractions. A study of 498 subjects

Domenico Sommariva; Adriana Branchi; Daniela Bonfiglioli; Maria Tirrito; Enrico Cabrini; Claudio Pini; Luciana Scandiani; Angelo Rovellini; Angelo Fasoli

doi:10.1007/BF02871805

Cholesterol distribution between HDL subfractions. A study of 498 subjects

Domenico Sommariva, Adriana Branchi, Daniela Bonfiglioli, Maria Tirrito, Enrico Cabrini, Claudio Pini, Luciana Scandiani, Angelo Rovellini, Angelo Fasoli

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL₂ than to that of HDL₃. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL₂ subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL₂- and HDL₃-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.

Original language	English
Pages (from-to)	165-172
Number of pages	8
Journal	La Ricerca in Clinica e in Laboratorio
Volume	19
Issue number	1
DOIs	https://doi.org/10.1007/BF02871805
Publication status	Published - Dec 1989

Keywords

HDL-cholesterol
HDL-cholesterol
HDL-cholesterol
Obesity
Serum lipoproteins

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02871805

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Cholesterol distribution between HDL subfractions. A study of 498 subjects. / Sommariva, Domenico; Branchi, Adriana; Bonfiglioli, Daniela; Tirrito, Maria; Cabrini, Enrico; Pini, Claudio; Scandiani, Luciana; Rovellini, Angelo; Fasoli, Angelo.

In: La Ricerca in Clinica e in Laboratorio, Vol. 19, No. 1, 12.1989, p. 165-172.

Research output: Contribution to journal › Article › peer-review

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AU - Sommariva, Domenico

AU - Branchi, Adriana

AU - Bonfiglioli, Daniela

AU - Tirrito, Maria

AU - Cabrini, Enrico

AU - Pini, Claudio

AU - Scandiani, Luciana

AU - Rovellini, Angelo

AU - Fasoli, Angelo

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N2 - In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL2 than to that of HDL3. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL2 subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL2- and HDL3-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.

AB - In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL2 than to that of HDL3. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL2 subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL2- and HDL3-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.

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