Cholesterol distribution between HDL subfractions. A study of 498 subjects

Domenico Sommariva, Adriana Branchi, Daniela Bonfiglioli, Maria Tirrito, Enrico Cabrini, Claudio Pini, Luciana Scandiani, Angelo Rovellini, Angelo Fasoli

Research output: Contribution to journalArticlepeer-review


In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL2 than to that of HDL3. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL2 subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL2- and HDL3-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1
Publication statusPublished - Dec 1989


  • HDL-cholesterol
  • HDL-cholesterol
  • HDL-cholesterol
  • Obesity
  • Serum lipoproteins

ASJC Scopus subject areas

  • Clinical Biochemistry


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