Cholesterol distribution between HDL subfractions. A study of 498 subjects.

D. Sommariva, A. Branchi, D. Bonfiglioli, M. Tirrito, E. Cabrini, C. Pini, L. Scandiani, A. Rovellini, A. Fasoli

Research output: Contribution to journalArticle


In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL2 than to that of HDL3. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL2 subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL2- and HDL3-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalLa Ricerca in Clinica e in Laboratorio
Issue number2
Publication statusPublished - Apr 1989


ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Sommariva, D., Branchi, A., Bonfiglioli, D., Tirrito, M., Cabrini, E., Pini, C., Scandiani, L., Rovellini, A., & Fasoli, A. (1989). Cholesterol distribution between HDL subfractions. A study of 498 subjects. La Ricerca in Clinica e in Laboratorio, 19(2), 165-172.