Cholesterol feeding to rats does not modulate the expression of binding sites for HDL on liver membranes

F. M. Maggi, A. L. Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

The binding of HDL, Apo-E-free, was studied in rats fed a cholesterol rich diet for 2, 4 and 7 days. Plasma cholesterol increased up to 16-fold (from 55 to 900 mg/dl); liver cholesterol was also raised, from 0.5 to 16 mg/g of tissue. The HDL binding to membrane preparations was not affected while the binding of β VLDL was reduced to about 50% of the controls. These data show, therefore, that liver binding sites for HDL are refractory to regulation by dietary cholesterol.

Original languageEnglish
Pages (from-to)1155-1157
Number of pages3
JournalExperientia
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 1986

Keywords

  • Apo-E
  • cholesterol feeding
  • HDL
  • liver membranes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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