Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

Micaela Gliozzi, Vincenzo Musolino, Francesca Bosco, Miriam Scicchitano, Federica Scarano, Saverio Nucera, Maria Caterina Zito, Stefano Ruga, Cristina Carresi, Roberta Macrì, Lorenza Guarnieri, Jessica Maiuolo, Annamaria Tavernese, Anna Rita Coppoletta, Caterina Nicita, Rocco Mollace, Ernesto Palma, Carolina Muscoli, Catherine Belzung, Vincenzo Mollace

Research output: Contribution to journalReview articlepeer-review

Abstract

Cholesterol homeostasis is a highly regulated process in human body because of its several functions underlying the biology of cell membranes, the synthesis of all steroid hormones and bile acids and the need of trafficking lipids destined to cell metabolism. In particular, it has been recognized that peripheral and central nervous system cholesterol metabolism are separated by the blood brain barrier and are regulated independently; indeed, peripherally, it depends on the balance between dietary intake and hepatic synthesis on one hand and its degradation on the other, whereas in central nervous system it is synthetized de novo to ensure brain physiology. In view of this complex metabolism and its relevant functions in mammalian, impaired levels of cholesterol can induce severe cellular dysfunction leading to metabolic, cardiovascular and neurodegenerative diseases. The aim of this review is to clarify the role of cholesterol homeostasis in health and disease highlighting new intriguing aspects of the cross talk between its central and peripheral metabolism.

Original languageEnglish
Article number105215
JournalPharmacological Research
Volume163
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Cardiovascular risk factors
  • Cholesterol homeostasis
  • Lipoproteins
  • miRNAs
  • Neurological diseases
  • Oxysterols

ASJC Scopus subject areas

  • Pharmacology

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