Cholesterol-rich rabbit serum modulates β-adrenergic receptor density of human lymphocytes: A possible role of LDL-cholesterol

C. Pieri, F. Moroni, R. Recchioni, M. Falasca, F. Marcheselli

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of in vitro treatment of human lymphocytes with rabbit cholesterol-rich serum (RCS) on the membrane microviscosity as well as on the β-adrenergic receptor density has been investigated. RCS treatment of cells resulted in a 30% decrease of receptor density without any effect on membrane microviscosity. A complete recovery was observed incubating the RCS cells either with the 'Active Lipids' (AL) or with heparin. The AL are a mixture of neutral lipids, phosphatidylcholine and phosphatidylethanolamine from hen egg yolk known to fluidify the cell membrane. The AL modified membrane microviscosity of control lymphocytes without altering their β-receptor number. These observations support the proposition that β-receptor density of human lymphocytes is not regulated by membrane microviscosity and suggest that probably low density lipoprotein-cholesterol complex is involved in such a regulation.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume650
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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