Choline alfoscerate: Short-term effect on sleep in healthy subjects

L. F. Strambi, M. Zucconi, V. Castronovo, C. Erminio, A. Marcone, S. Smirne

Research output: Contribution to journalArticlepeer-review


A single-blind controlled polysomnographic study was conducted in eight healthy young male subjects to assess the effect of a cholinomimetic drug, choline alfoscerate (α-GPC), on sleep. The aim of the study was to determine whether short-term treatment with 400 mg of α-GPC TID modified sleep and, in particular, rapid-eye-movement (REM) sleep parameters. Neither sleep-induction, sleep maintenance nor sleep stage percentages were affected by α-GPC. REM sleep latency was not modified, while REM density was slightly increased. The failure to modify the architecture of sleep is noteworthy in view of the potential use of this compound for aged subjects.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalCurrent Therapeutic Research
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Medicine(all)


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