Cholinergic activity correlates with reserve proxies in Alzheimer's disease

Valentina Garibotto, Marco Tettamanti, Alessandra Marcone, Ioana Florea, Andrea Panzacchi, Rosamaria Moresco, Jere R. Virta, Juha Rinne, Stefano F. Cappa, Daniela Perani

Research output: Contribution to journalArticle

Abstract

The clinical expression of Alzheimer's disease (AD) occurs as neuropathology exceeds the brain "reserve capacity." A possible association between the cholinergic system and reserve is suggested by preclinical observations that the cholinergic system allows cortical plasticity and by clinical observations of variable responses to cholinergic treatments depending on the patient's educational level. The aim of this study was to investigate the association of reserve proxies, that is, education and occupation, with acetylcholinesterase (AChE) activity, measured voxelwise by [11C]-MP4A and positron emission tomography (PET), in 9 healthy controls (HC), 7 patients with early probable AD, and 9 subjects with mild cognitive impairment (MCI) at the time of PET imaging, who progressed to AD at follow-up (prodromal AD). The analysis of prodromal and early AD showed positive correlations between education and AChE activity in the hippocampus, bilaterally, and between occupation and AChE activity in the right posterior cingulate gyrus. The significant correlation between AChE activity in structures belonging to the memory network and reserve proxies suggests that the brain reserve in AD is associated with a preserved/stimulated cholinergic neurotransmission.

Original languageEnglish
JournalNeurobiology of Aging
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Proxy
Cholinergic Agents
Acetylcholinesterase
Alzheimer Disease
Cognitive Reserve
Occupations
Positron-Emission Tomography
Education
Gyrus Cinguli
Synaptic Transmission
Hippocampus

Keywords

  • Acetylcholinesterase (AChE) activity
  • Alzheimer's disease (AD)
  • Positron emission tomography (PET)
  • Reserve

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Cholinergic activity correlates with reserve proxies in Alzheimer's disease. / Garibotto, Valentina; Tettamanti, Marco; Marcone, Alessandra; Florea, Ioana; Panzacchi, Andrea; Moresco, Rosamaria; Virta, Jere R.; Rinne, Juha; Cappa, Stefano F.; Perani, Daniela.

In: Neurobiology of Aging, Vol. 34, No. 11, 11.2013.

Research output: Contribution to journalArticle

Garibotto, V, Tettamanti, M, Marcone, A, Florea, I, Panzacchi, A, Moresco, R, Virta, JR, Rinne, J, Cappa, SF & Perani, D 2013, 'Cholinergic activity correlates with reserve proxies in Alzheimer's disease', Neurobiology of Aging, vol. 34, no. 11. https://doi.org/10.1016/j.neurobiolaging.2013.05.020
Garibotto, Valentina ; Tettamanti, Marco ; Marcone, Alessandra ; Florea, Ioana ; Panzacchi, Andrea ; Moresco, Rosamaria ; Virta, Jere R. ; Rinne, Juha ; Cappa, Stefano F. ; Perani, Daniela. / Cholinergic activity correlates with reserve proxies in Alzheimer's disease. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 11.
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