Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation

Laura Ricceri; Bianca De Filippis; Andrea Fuso; Giovanni Laviola

doi:10.1016/j.bbr.2011.03.051

Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation

Laura Ricceri, Bianca De Filippis, Andrea Fuso, Giovanni Laviola

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome. Adult male mutant hemizygous (hz) mice showed a reduction of locomotor activity compared to wild type (wt) littermates. Early choline treatment restored wt-like locomotor activity levels in hz mice. Reduced striatal choline acetyl transferase (ChAT) activity and decreased levels of cortical mRNA NGF were found in hz mice. Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions. As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype.

Original language	English
Pages (from-to)	623-629
Number of pages	7
Journal	Behavioural Brain Research
Volume	221
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2011.03.051
Publication status	Published - Aug 10 2011

Keywords

Behavioural phenotyping
Cholinergic system
Neurotrophines
Nutritional factors
Rett syndrome
Scopolamine

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2011.03.051

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title = "Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation",

abstract = "We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome. Adult male mutant hemizygous (hz) mice showed a reduction of locomotor activity compared to wild type (wt) littermates. Early choline treatment restored wt-like locomotor activity levels in hz mice. Reduced striatal choline acetyl transferase (ChAT) activity and decreased levels of cortical mRNA NGF were found in hz mice. Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions. As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype.",

keywords = "Behavioural phenotyping, Cholinergic system, Neurotrophines, Nutritional factors, Rett syndrome, Scopolamine",

author = "Laura Ricceri and {De Filippis}, Bianca and Andrea Fuso and Giovanni Laviola",

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AU - Ricceri, Laura

AU - De Filippis, Bianca

AU - Fuso, Andrea

AU - Laviola, Giovanni

PY - 2011/8/10

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KW - Scopolamine

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Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation

Abstract

Keywords

ASJC Scopus subject areas

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