Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation

Laura Ricceri, Bianca De Filippis, Andrea Fuso, Giovanni Laviola

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the long-term effects of a postnatal choline supplementation (from birth till weaning) in the truncated MeCP2-308 mouse model of Rett syndrome. Adult male mutant hemizygous (hz) mice showed a reduction of locomotor activity compared to wild type (wt) littermates. Early choline treatment restored wt-like locomotor activity levels in hz mice. Reduced striatal choline acetyl transferase (ChAT) activity and decreased levels of cortical mRNA NGF were found in hz mice. Choline supplementation increased striatal ChAT activity and also enhanced NGF and BDNF expression in cortical and hippocampal regions. As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalBehavioural Brain Research
Volume221
Issue number2
DOIs
Publication statusPublished - Aug 10 2011

Keywords

  • Behavioural phenotyping
  • Cholinergic system
  • Neurotrophines
  • Nutritional factors
  • Rett syndrome
  • Scopolamine

ASJC Scopus subject areas

  • Behavioral Neuroscience

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