Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia

Giovanni Murialdo, Francesco Zerbi, Ugo Filippi, Pietro Tosca, Stefano Fonzi, Finita Di Paolo, Falrizia Coslelli, Savino Forro, Alessandro Polleri, Faustino Savoldi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An impairment of cholinergic and somatostatinergic neurotransmission have been reported in dementia. Both acetylcholine and somatostatin are involved in the regulation of growth hormonc (GH) secretion. The effects of GH-releasing hormone (GHRH) 1-44 on GH release have been studied before and after the pretreatment with pyridostigmine or pirenzepine in subjects with senile dementia of the Alzheimer type, multi-infarct dementia and mixed dementia. The data have been compared with those obtained in an age-matched healthy control group. The GH response to GHRH is similar in the patients and in the controls, though the peak occurrence is significantly delayed in dementia. The Cholinesterase inhibitor pyridostigmine enhances significantly the GH response to GHRH in both groups. The responses obtained in demented subjeets are significantly larger than those found in the controls. Pirenzepine. a muscarinic receptor blocker, inhibits the GHRH effect on GH secretion in both groups. The findings may be interpreted in terms of an underlying impairment of the hypothalamic cholinergic neurotransmission, with an acetylcholine reeeptor supersensitivity that becomes apparent when the cholinergic tonus is enhanced by the inhibition of cholinesterase by pyridostigmine. No significant differences, due to the type of dementia, have been observed.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalNeuropsychobiology
Volume24
Issue number3
DOIs
Publication statusPublished - 1990

Fingerprint

Growth Hormone-Releasing Hormone
Cholinergic Agents
Growth Hormone
Dementia
Pyridostigmine Bromide
Growth
Hormones
Pirenzepine
Synaptic Transmission
Acetylcholine
Multi-Infarct Dementia
Cholinesterase Inhibitors
Cholinesterases
Muscarinic Receptors
Somatostatin
Alzheimer Disease
Control Groups

Keywords

  • Cholinergic System
  • Dementia
  • Growth hormone
  • Growth hormone-releasing hormone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Murialdo, G., Zerbi, F., Filippi, U., Tosca, P., Fonzi, S., Di Paolo, F., ... Savoldi, F. (1990). Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia. Neuropsychobiology, 24(3), 129-134. https://doi.org/10.1159/000119475

Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia. / Murialdo, Giovanni; Zerbi, Francesco; Filippi, Ugo; Tosca, Pietro; Fonzi, Stefano; Di Paolo, Finita; Coslelli, Falrizia; Forro, Savino; Polleri, Alessandro; Savoldi, Faustino.

In: Neuropsychobiology, Vol. 24, No. 3, 1990, p. 129-134.

Research output: Contribution to journalArticle

Murialdo, G, Zerbi, F, Filippi, U, Tosca, P, Fonzi, S, Di Paolo, F, Coslelli, F, Forro, S, Polleri, A & Savoldi, F 1990, 'Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia', Neuropsychobiology, vol. 24, no. 3, pp. 129-134. https://doi.org/10.1159/000119475
Murialdo, Giovanni ; Zerbi, Francesco ; Filippi, Ugo ; Tosca, Pietro ; Fonzi, Stefano ; Di Paolo, Finita ; Coslelli, Falrizia ; Forro, Savino ; Polleri, Alessandro ; Savoldi, Faustino. / Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia. In: Neuropsychobiology. 1990 ; Vol. 24, No. 3. pp. 129-134.
@article{5db0b99ec50043d9a3378a47abc98ec8,
title = "Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia",
abstract = "An impairment of cholinergic and somatostatinergic neurotransmission have been reported in dementia. Both acetylcholine and somatostatin are involved in the regulation of growth hormonc (GH) secretion. The effects of GH-releasing hormone (GHRH) 1-44 on GH release have been studied before and after the pretreatment with pyridostigmine or pirenzepine in subjects with senile dementia of the Alzheimer type, multi-infarct dementia and mixed dementia. The data have been compared with those obtained in an age-matched healthy control group. The GH response to GHRH is similar in the patients and in the controls, though the peak occurrence is significantly delayed in dementia. The Cholinesterase inhibitor pyridostigmine enhances significantly the GH response to GHRH in both groups. The responses obtained in demented subjeets are significantly larger than those found in the controls. Pirenzepine. a muscarinic receptor blocker, inhibits the GHRH effect on GH secretion in both groups. The findings may be interpreted in terms of an underlying impairment of the hypothalamic cholinergic neurotransmission, with an acetylcholine reeeptor supersensitivity that becomes apparent when the cholinergic tonus is enhanced by the inhibition of cholinesterase by pyridostigmine. No significant differences, due to the type of dementia, have been observed.",
keywords = "Cholinergic System, Dementia, Growth hormone, Growth hormone-releasing hormone",
author = "Giovanni Murialdo and Francesco Zerbi and Ugo Filippi and Pietro Tosca and Stefano Fonzi and {Di Paolo}, Finita and Falrizia Coslelli and Savino Forro and Alessandro Polleri and Faustino Savoldi",
year = "1990",
doi = "10.1159/000119475",
language = "English",
volume = "24",
pages = "129--134",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia

AU - Murialdo, Giovanni

AU - Zerbi, Francesco

AU - Filippi, Ugo

AU - Tosca, Pietro

AU - Fonzi, Stefano

AU - Di Paolo, Finita

AU - Coslelli, Falrizia

AU - Forro, Savino

AU - Polleri, Alessandro

AU - Savoldi, Faustino

PY - 1990

Y1 - 1990

N2 - An impairment of cholinergic and somatostatinergic neurotransmission have been reported in dementia. Both acetylcholine and somatostatin are involved in the regulation of growth hormonc (GH) secretion. The effects of GH-releasing hormone (GHRH) 1-44 on GH release have been studied before and after the pretreatment with pyridostigmine or pirenzepine in subjects with senile dementia of the Alzheimer type, multi-infarct dementia and mixed dementia. The data have been compared with those obtained in an age-matched healthy control group. The GH response to GHRH is similar in the patients and in the controls, though the peak occurrence is significantly delayed in dementia. The Cholinesterase inhibitor pyridostigmine enhances significantly the GH response to GHRH in both groups. The responses obtained in demented subjeets are significantly larger than those found in the controls. Pirenzepine. a muscarinic receptor blocker, inhibits the GHRH effect on GH secretion in both groups. The findings may be interpreted in terms of an underlying impairment of the hypothalamic cholinergic neurotransmission, with an acetylcholine reeeptor supersensitivity that becomes apparent when the cholinergic tonus is enhanced by the inhibition of cholinesterase by pyridostigmine. No significant differences, due to the type of dementia, have been observed.

AB - An impairment of cholinergic and somatostatinergic neurotransmission have been reported in dementia. Both acetylcholine and somatostatin are involved in the regulation of growth hormonc (GH) secretion. The effects of GH-releasing hormone (GHRH) 1-44 on GH release have been studied before and after the pretreatment with pyridostigmine or pirenzepine in subjects with senile dementia of the Alzheimer type, multi-infarct dementia and mixed dementia. The data have been compared with those obtained in an age-matched healthy control group. The GH response to GHRH is similar in the patients and in the controls, though the peak occurrence is significantly delayed in dementia. The Cholinesterase inhibitor pyridostigmine enhances significantly the GH response to GHRH in both groups. The responses obtained in demented subjeets are significantly larger than those found in the controls. Pirenzepine. a muscarinic receptor blocker, inhibits the GHRH effect on GH secretion in both groups. The findings may be interpreted in terms of an underlying impairment of the hypothalamic cholinergic neurotransmission, with an acetylcholine reeeptor supersensitivity that becomes apparent when the cholinergic tonus is enhanced by the inhibition of cholinesterase by pyridostigmine. No significant differences, due to the type of dementia, have been observed.

KW - Cholinergic System

KW - Dementia

KW - Growth hormone

KW - Growth hormone-releasing hormone

UR - http://www.scopus.com/inward/record.url?scp=0025553855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025553855&partnerID=8YFLogxK

U2 - 10.1159/000119475

DO - 10.1159/000119475

M3 - Article

VL - 24

SP - 129

EP - 134

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 3

ER -