Cholinergic stimulation of human microcitoma cell line H69

Sergio Fucile, Maddalena Napolitano, Elisabetta Mattei

Research output: Contribution to journalArticle

Abstract

Experiments were addressed to investigate the mechanisms by which cholinergic stimulation is coupled to the enhancement of proliferation of small cell lung cancer cells H69. Muscarinic stimulation triggers the release of cytosolic Ca2+ and of inositol(1,4,5)trisphosphate with comparable time courses. The presence of α-bungarotoxin or the absence of Ca2+ in external medium suppresses enhancement of clonal growth induced by brief applications of nicotine. Here we suggest that Ca2+ mobilization represents a trigger for the enhancement of small cell lung cancer cell proliferation upon cholinergic stimulation.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume230
Issue number3
DOIs
Publication statusPublished - Jan 23 1997

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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