Choosing the right cell line for renal cell cancer research

Klaudia K. Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta, Anna M. Czarnecka

Research output: Contribution to journalReview article

Abstract

Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Therapeutics against renal cell cancer (RCC) are also screened with the use of cell lines. Multiple RCC in vitro cultures are available, allowing in vivo heterogeneity in the laboratory, but at the same time, these can be a source of errors. In this review, we tried to sum up the data on the RCC cell lines used currently. An increasing amount of data on RCC shed new light on the molecular background of the disease; however, it revealed how much still needs to be done. As new types of RCC are being distinguished, novel cell lines and the re-exploration of old ones seems to be indispensable to create effective in vitro tools for drug screening and more.

Original languageEnglish
Article number83
JournalMolecular Cancer
Volume15
Issue number1
DOIs
Publication statusPublished - Dec 19 2016

Keywords

  • Cell lines
  • Clear cell RCC
  • In vitro RCC
  • Papillary RCC
  • Renal cell cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

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  • Cite this

    Brodaczewska, K. K., Szczylik, C., Fiedorowicz, M., Porta, C., & Czarnecka, A. M. (2016). Choosing the right cell line for renal cell cancer research. Molecular Cancer, 15(1), [83]. https://doi.org/10.1186/s12943-016-0565-8