Chordoid glioma: A rare radiologically, histologically, and clinically mystifying lesion

Daniele Bongetta, Andrea Risso, Patrizia Morbini, Giorgio Butti, Paolo Gaetani

Research output: Contribution to journalArticlepeer-review


Chordoid glioma (CG) is a rare central nervous system neoplasm (WHO grade II) of uncertain origin whose typical localization is in the anterior part of the third ventricle. Its clinical, radiological, and histological features may vary and furthermore mimic other kind of benign lesions usually associated with a better outcome. We report a case of a 43-year-old female who underwent gross total removal of a lesion of the third ventricle causing hydrocephalus. The imaging studies and the intraoperative examination led at first to a hypothesis of meningioma. Early surgical and neurological outcomes were good. The patient underwent multiple complications related to hypothalamic dysfunctions and thrombohemorragic issues and eventually died because of systemic infections. Definitive examination was of chordoid glioma of the third ventricle. Reviewing literature, we evaluated possible pitfalls in radiological and histological diagnosis as well as in surgical and medical treatment of CGs. Despite their benign presentation, a high incidence of multiple possible severe complications is reported. Early alertness and combined treatment strategies could improve overall CGs treatment strategies.

Original languageEnglish
Article number188
JournalWorld Journal of Surgical Oncology
Issue number1
Publication statusPublished - May 28 2015


  • Chordoid
  • Chordoid glioma
  • Glioma
  • Third ventricle

ASJC Scopus subject areas

  • Oncology
  • Surgery


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