Chordoid meningioma: A retrospective series of seven consecutive cases

Emiliano Passacantilli, Gennaro Lapadula, Federico Caporlingua, Jacopo Lenzi, Manila Antonelli, Francesca Santoro, Antonio Santoro

Research output: Contribution to journalArticlepeer-review


Chordoid meningioma is a rare variant of meningioma characterized by a more aggressive behavior. The present study documents the histological, radiological and clinical features of seven cases treated at the Policlinico Umberto I of Rome from 1999 to 2010. There were five males and two females. Most of the cases were located in the supratentorial space, especially the convexity. Surgical gross total resection was achieved in four cases. Of the remaining three cases, two relapsed and underwent further surgeries and adjuvant treatment. The MIB-1 index had a mean value of 7.5 (range 0.3-25.8). Tumors were composed of epithelioid cells or plump to spindle cells, forming cords, cribriforms or nests, in a mucoid matrix. All tumors showed diffuse positive immunoreactivity to vimentin and epithelial membrane antigen. Surgery is the first line of treatment for this kind of lesion. Gross total resection guaranteed a survival free from recurrences in our series. On the other hand, radiation therapy must be considered in patients submitted to a subtotal resection.

Original languageEnglish
Pages (from-to)1985-1989
Number of pages5
JournalNeurological Sciences
Issue number11
Publication statusPublished - Nov 2013


  • Brain neoplasm
  • Intracranial meningioma
  • Meningioma: radiotherapy
  • Meningioma: surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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