Abstract
Chordomas and chondrosarcomas (CC) of the skull base are rare accounting for 0.1-0.2% of all intracranial tumors. These neoplasms represent a challenge for the neurosurgeon because of their proximity to vital neurovascular structures. Although CC are generally regarded as slow-growing tumors, shortterm recurrencies after surgical treatment are not uncommon. However, the pathological features that have yet been investigated are poor predictors of outcome. We have retrospectively analysed a series of 24 patients with CC of the cranial base (14 males, 10 females; age 17-84 years) who were surgically treated at our institution since January 1988. Tumor location was as follows, upper clivus 4 cases, middle clivus 13, lower clivus 4, and petrous bone 3. The tumor extended to the anterior skull base and orbit in 2 cases and to C1-C2 in 4. The cavernous sinus was involved in 6 cases. In one case, the tumor was primarily retropharyngeal in location and infiltrated the clivai bone at a later stage. One case also had a vertebral chordoma at the thoracic level, another case developed pulmonary métastases. A total of 40 surgical procedures were performed, that included transsphenoidal approaches 22, trans-maxillary 5, extreme lateral (EL) 4, extended subfrontal 2, orbito-zygomatic 2, trans-oral 2, suboccipital 1, fronto-temporal 1, combined subtemporal-infratemporal and EL 1. Total removal (absence of tumor on microsurgical inspection and on MRI at 3 months after surgery) was achieved in 9 cases. In 10 cases, a subtotal removal was done (resection of 80% of tumor), and in 5 cases the tumor was partly removed (resection
| Original language | English |
|---|---|
| Pages (from-to) | 20-21 |
| Number of pages | 2 |
| Journal | Skull Base |
| Volume | 11 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Clinical Neurology
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Chordoma and chondrosarcoma of the skull base. A series of 24 surgically treated cases and factors predicting early tumor recurrence. / Maira, Giulio; Pallini, Roberta; Femandez, Eduardo; Anile, Carmelo; Massimi, Luca; Pierconti, Francesco; Larocca, Luigi M.; Falchetti, Maria Laura; Cimino-Reale, Graziella; 'Ambrosia, Ettore D.
In: Skull Base, Vol. 11, No. SUPPL. 2, 2001, p. 20-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chordoma and chondrosarcoma of the skull base. A series of 24 surgically treated cases and factors predicting early tumor recurrence
AU - Maira, Giulio
AU - Pallini, Roberta
AU - Femandez, Eduardo
AU - Anile, Carmelo
AU - Massimi, Luca
AU - Pierconti, Francesco
AU - Larocca, Luigi M.
AU - Falchetti, Maria Laura
AU - Cimino-Reale, Graziella
AU - 'Ambrosia, Ettore D.
PY - 2001
Y1 - 2001
N2 - Chordomas and chondrosarcomas (CC) of the skull base are rare accounting for 0.1-0.2% of all intracranial tumors. These neoplasms represent a challenge for the neurosurgeon because of their proximity to vital neurovascular structures. Although CC are generally regarded as slow-growing tumors, shortterm recurrencies after surgical treatment are not uncommon. However, the pathological features that have yet been investigated are poor predictors of outcome. We have retrospectively analysed a series of 24 patients with CC of the cranial base (14 males, 10 females; age 17-84 years) who were surgically treated at our institution since January 1988. Tumor location was as follows, upper clivus 4 cases, middle clivus 13, lower clivus 4, and petrous bone 3. The tumor extended to the anterior skull base and orbit in 2 cases and to C1-C2 in 4. The cavernous sinus was involved in 6 cases. In one case, the tumor was primarily retropharyngeal in location and infiltrated the clivai bone at a later stage. One case also had a vertebral chordoma at the thoracic level, another case developed pulmonary métastases. A total of 40 surgical procedures were performed, that included transsphenoidal approaches 22, trans-maxillary 5, extreme lateral (EL) 4, extended subfrontal 2, orbito-zygomatic 2, trans-oral 2, suboccipital 1, fronto-temporal 1, combined subtemporal-infratemporal and EL 1. Total removal (absence of tumor on microsurgical inspection and on MRI at 3 months after surgery) was achieved in 9 cases. In 10 cases, a subtotal removal was done (resection of 80% of tumor), and in 5 cases the tumor was partly removed (resection
AB - Chordomas and chondrosarcomas (CC) of the skull base are rare accounting for 0.1-0.2% of all intracranial tumors. These neoplasms represent a challenge for the neurosurgeon because of their proximity to vital neurovascular structures. Although CC are generally regarded as slow-growing tumors, shortterm recurrencies after surgical treatment are not uncommon. However, the pathological features that have yet been investigated are poor predictors of outcome. We have retrospectively analysed a series of 24 patients with CC of the cranial base (14 males, 10 females; age 17-84 years) who were surgically treated at our institution since January 1988. Tumor location was as follows, upper clivus 4 cases, middle clivus 13, lower clivus 4, and petrous bone 3. The tumor extended to the anterior skull base and orbit in 2 cases and to C1-C2 in 4. The cavernous sinus was involved in 6 cases. In one case, the tumor was primarily retropharyngeal in location and infiltrated the clivai bone at a later stage. One case also had a vertebral chordoma at the thoracic level, another case developed pulmonary métastases. A total of 40 surgical procedures were performed, that included transsphenoidal approaches 22, trans-maxillary 5, extreme lateral (EL) 4, extended subfrontal 2, orbito-zygomatic 2, trans-oral 2, suboccipital 1, fronto-temporal 1, combined subtemporal-infratemporal and EL 1. Total removal (absence of tumor on microsurgical inspection and on MRI at 3 months after surgery) was achieved in 9 cases. In 10 cases, a subtotal removal was done (resection of 80% of tumor), and in 5 cases the tumor was partly removed (resection
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UR - http://www.scopus.com/inward/citedby.url?scp=33747811768&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 20
EP - 21
JO - Skull Base
JF - Skull Base
SN - 1531-5010
IS - SUPPL. 2
ER -