Chorea mollis: Long-term follow-up of an infantile case

Umberto Balottin, Elena Calcaterra, Fabio Zambonin, Pierangelo Veggiotti, Chiara Luoni, Cristiano Termine

Research output: Contribution to journalArticlepeer-review


We describe the long-term follow-up of a patient affected by chorea mollis, a rare variant of Sydenham's chorea of which there are very few reports in the literature. Our patient, a previously healthy 8-year-old boy developed progressive clumsiness, gait disturbance, generalized hypotonia and muscle weakness, choreic movements of the limbs and behavioural disturbances. Following the diagnosis of chorea mollis, the patient received prophylaxis (monthly injections of benzathine benzyl penicillin). Within a few weeks, his clinical conditions worsened and he became bedridden and incapable of standing and walking without assistance. The choreic movements were successfully treated with sodium valproate. Independent walking was achieved 14 months after the onset of the disease. At a4-year follow-up, the patient showed a full neurological and psychiatric recovery. The clinical course observed in our patient shows that chorea mollis may not only have a dramatic course, but also have a good long-term prognosis.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalNeurological Sciences
Issue number3
Publication statusPublished - Jun 2012


  • Chorea mollis
  • Follow-up
  • Outcome
  • Sydenham's chorea

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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