Choroidal caverns: A previously unreported optical coherence tomography finding in best vitelliform dystrophy

Adriano Carnevali, R Sacconi, Eleonora Corbelli, L Querques, F Bandello, G Querques

Research output: Contribution to journalArticle

Abstract

Best vitelliform macular dystrophy (VMD) is an autosomal dominant inherited dystrophy, most frequently caused by mutations in the BEST1 gene. The authors describe “choroidal caverns,” a previously unreported optical coherence tomography finding in the choriocapillary and choroid of Best VMD. Histopathologic examination in eyes with Best VDM shows extensive deposition of lipofuscin in the retinal pigment epithelium (RPE) throughout the retina and accumulation of fibrillar material under the RPE and in the choroid. This supports the hypothesis that choroidal caverns could be a sign of the degenerative process involving the choroid in eyes with Best VMD. © 2018 Slack Incorporated. All rights reserved.
Original languageEnglish
Pages (from-to)284-287
Number of pages4
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume49
Issue number4
DOIs
Publication statusPublished - 2018

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Vitelliform Macular Dystrophy
Choroid
Optical Coherence Tomography
Retinal Pigment Epithelium
Lipofuscin
Retina
Mutation
Genes

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Choroidal caverns: A previously unreported optical coherence tomography finding in best vitelliform dystrophy. / Carnevali, Adriano; Sacconi, R; Corbelli, Eleonora; Querques, L; Bandello, F; Querques, G.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 49, No. 4, 2018, p. 284-287.

Research output: Contribution to journalArticle

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