TY - JOUR
T1 - Choroidal neovascular membrane following hormonal stimulation for in vitro fertilization
AU - Ciucci, Francesco
AU - Sacchetti, Marta
AU - De Gaetano, Cristiano
AU - Bardocci, Antonio
AU - Lofoco, Giorgio
PY - 2015/4/2
Y1 - 2015/4/2
N2 - Purpose: To report the onset of choroidal neovascularization (CNV) following hormonal stimulation for in vitro fertilization (IVF) in a healthy young woman. Methods: A 31-year-old woman presented with visual impairment following hormonal stimulation for IVF. Clinical history was collected and best-corrected visual acuity (BCVA), complete eye examination, optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography were performed. Results: Clinical history was negative with the exception of the use of medications for IVF in the previous weeks. Ocular examination revealed the presence of a CNV in the right eye, confirmed by OCT and FA, with a BCVA of 0.7 decimal units. Possible ocular and systemic diseases associated with CNV development were investigated and excluded. Treatment with 3 monthly intravitreal injections of anti–vascular endothelial growth factor (VEGF) was effective in reducing CNV size and restoring visual acuity. Conclusions: This is the first report describing the development of CNV following hormonal stimulation for IVF. The development of CNV may be associated with changes of sex hormones, cytokines, and angiogenic factor levels, including VEGF, induced by hormonal stimulation.
AB - Purpose: To report the onset of choroidal neovascularization (CNV) following hormonal stimulation for in vitro fertilization (IVF) in a healthy young woman. Methods: A 31-year-old woman presented with visual impairment following hormonal stimulation for IVF. Clinical history was collected and best-corrected visual acuity (BCVA), complete eye examination, optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography were performed. Results: Clinical history was negative with the exception of the use of medications for IVF in the previous weeks. Ocular examination revealed the presence of a CNV in the right eye, confirmed by OCT and FA, with a BCVA of 0.7 decimal units. Possible ocular and systemic diseases associated with CNV development were investigated and excluded. Treatment with 3 monthly intravitreal injections of anti–vascular endothelial growth factor (VEGF) was effective in reducing CNV size and restoring visual acuity. Conclusions: This is the first report describing the development of CNV following hormonal stimulation for IVF. The development of CNV may be associated with changes of sex hormones, cytokines, and angiogenic factor levels, including VEGF, induced by hormonal stimulation.
KW - Choroidal neovascularization
KW - In vitro fertilization
KW - Retina
KW - Sex hormones
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=84940043581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940043581&partnerID=8YFLogxK
U2 - 10.5301/ejo.5000607
DO - 10.5301/ejo.5000607
M3 - Article
C2 - 25837641
AN - SCOPUS:84940043581
VL - 25
SP - e95-e97
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
SN - 1120-6721
IS - 5
ER -