Choroidal neovascularization in multifocal choroiditis after dabrafenib and trametinib

GC Albertini, Eleonora Corbelli, M Battaglia Parodi, F Bandello

Research output: Contribution to journalArticlepeer-review


Purpose: To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma. Case: We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days’ duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed. Conclusions: This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis. © 2017 Wichtig Publishing.
Original languageEnglish
Pages (from-to)e184-e186
JournalEuropean Journal of Ophthalmology
Issue number6
Publication statusPublished - 2017


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