Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome

Marco Pellegrini, Chiara Veronese, Federico Bernabei, Marco Lupidi, Alessio Cerquaglia, Alessandro Invernizzi, Federico Zicarelli, Luca Cimino, Elena Bolletta, Aldo Vagge, Antonio P. Ciardella

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate choroidal structural changes in patients with multiple evanescent white dot syndrome (MEWDS) during the acute and recovery stages. Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 16 patients with unilateral MEWDS were acquired during the acute and recovery stages in both eyes. Images were binarized with the ImageJ software to measure subfoveal choroidal thickness (CT), total choroid area, luminal area and choroidal vascularity index (CVI). Results: In the acute stage, subfoveal CT, total choroidal area and CVI were significantly higher in eyes with MEWDS compared to fellow eyes (371.2 ± 101.8 vs 317.1 ± 90.3 µm, p = .001; 2.826 ± 0.686 vs 2.524 ± 0.674 mm2, p = .014; 69.49 ± 3.51 vs 68.27 ± 3.41%, p = .044, respectively). In the recovery stage, subfoveal CT, total choroidal area and CVI in eyes with MEWDS significantly decreased to respectively 333.4 ± 90.5 µm, p = .007, 2.592 ± 0.570 p = .002, and 67.31 ± 2.74%, p = .014. Conclusions: Choroidal thickness and vascularity are significantly increased during the acute stage of MEWDS.

Original languageEnglish
JournalOcular Immunology and Inflammation
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • Choroidal thickness
  • choroidal vascularity index
  • enhanced depth imaging
  • multiple evanescent white dot syndrome
  • optical coherence tomography

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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