TY - JOUR
T1 - Choroidal Vascular Changes in Multiple Evanescent White Dot Syndrome
AU - Pellegrini, Marco
AU - Veronese, Chiara
AU - Bernabei, Federico
AU - Lupidi, Marco
AU - Cerquaglia, Alessio
AU - Invernizzi, Alessandro
AU - Zicarelli, Federico
AU - Cimino, Luca
AU - Bolletta, Elena
AU - Vagge, Aldo
AU - Ciardella, Antonio P.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: To evaluate choroidal structural changes in patients with multiple evanescent white dot syndrome (MEWDS) during the acute and recovery stages. Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 16 patients with unilateral MEWDS were acquired during the acute and recovery stages in both eyes. Images were binarized with the ImageJ software to measure subfoveal choroidal thickness (CT), total choroid area, luminal area and choroidal vascularity index (CVI). Results: In the acute stage, subfoveal CT, total choroidal area and CVI were significantly higher in eyes with MEWDS compared to fellow eyes (371.2 ± 101.8 vs 317.1 ± 90.3 µm, p = .001; 2.826 ± 0.686 vs 2.524 ± 0.674 mm2, p = .014; 69.49 ± 3.51 vs 68.27 ± 3.41%, p = .044, respectively). In the recovery stage, subfoveal CT, total choroidal area and CVI in eyes with MEWDS significantly decreased to respectively 333.4 ± 90.5 µm, p = .007, 2.592 ± 0.570 p = .002, and 67.31 ± 2.74%, p = .014. Conclusions: Choroidal thickness and vascularity are significantly increased during the acute stage of MEWDS.
AB - Purpose: To evaluate choroidal structural changes in patients with multiple evanescent white dot syndrome (MEWDS) during the acute and recovery stages. Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 16 patients with unilateral MEWDS were acquired during the acute and recovery stages in both eyes. Images were binarized with the ImageJ software to measure subfoveal choroidal thickness (CT), total choroid area, luminal area and choroidal vascularity index (CVI). Results: In the acute stage, subfoveal CT, total choroidal area and CVI were significantly higher in eyes with MEWDS compared to fellow eyes (371.2 ± 101.8 vs 317.1 ± 90.3 µm, p = .001; 2.826 ± 0.686 vs 2.524 ± 0.674 mm2, p = .014; 69.49 ± 3.51 vs 68.27 ± 3.41%, p = .044, respectively). In the recovery stage, subfoveal CT, total choroidal area and CVI in eyes with MEWDS significantly decreased to respectively 333.4 ± 90.5 µm, p = .007, 2.592 ± 0.570 p = .002, and 67.31 ± 2.74%, p = .014. Conclusions: Choroidal thickness and vascularity are significantly increased during the acute stage of MEWDS.
KW - Choroidal thickness
KW - choroidal vascularity index
KW - enhanced depth imaging
KW - multiple evanescent white dot syndrome
KW - optical coherence tomography
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U2 - 10.1080/09273948.2019.1678650
DO - 10.1080/09273948.2019.1678650
M3 - Article
C2 - 31697565
AN - SCOPUS:85074829761
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
ER -