CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer's Disease Patients

Ferdinando Clarelli, Elisabetta Mascia, Roberto Santangelo, Salvatore Mazzeo, Giacomo Giacalone, Daniela Galimberti, Federica Fusco, Marta Zuffi, Chiara Fenoglio, Massimo Franceschi, Elio Scarpini, Gianluigi Forloni, Giuseppe Magnani, Giancarlo Comi, Diego Albani, Filippo Martinelli Boneschi

Research output: Contribution to journalArticle

Abstract

Previous studies suggest that genetic variants in CHRNA7, which encodes for the major subunit of the acetylcholine receptor (α7-nAChR), are associated with the clinical response to cholinesterase inhibitors (ChEI) in Alzheimer's disease (AD) patients. We sought to replicate the association of two SNPs in the CHRNA7 gene, rs6494223 and rs8024987, with response to ChEI treatment in an Italian cohort of 169 AD patients, further extending the study to gene-level analysis. None of the tested variants was associated with clinical response. However, rs6494223 showed a consistent effect direction (OR=1.4; p=0.17), which after meta-analysis with previous study yielded a significant result (OR=1.57, p=0.02, I2=0).

Original languageEnglish
Pages (from-to)1203-1208
Number of pages6
JournalJournal of Alzheimer's Disease
Volume52
Issue number4
DOIs
Publication statusPublished - 2016

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Keywords

  • Alpha7 nicotinic acetylcholine receptor
  • Alzheimer's disease
  • biomarkers
  • cholinesterase inhibitors
  • pharmacogenetics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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