Chromas from chromatin

Sonification of the epigenome

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The epigenetic modifications are organized in patterns determining the functional properties of the underlying genome. Such patterns, typically measured by ChIP-seq assays of histone modifications, can be combined and translated into musical scores, summarizing multiple signals into a single waveform. As music is recognized as a universal way to convey meaningful information, we wanted to investigate properties of music obtained by sonification of ChIP-seq data. We show that the music produced by such quantitative signals is perceived by human listeners as more pleasant than that produced from randomized signals. Moreover, the waveform can be analyzed to predict phenotypic properties, such as differential gene expression.

Original languageEnglish
Article number274
JournalF1000Research
Volume5
DOIs
Publication statusPublished - 2016

Fingerprint

Music
Gene expression
Histones
Chromatin
Assays
Genes
Histone Code
Epigenomics
Genome
Gene Expression

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chromas from chromatin : Sonification of the epigenome. / Cittaro, Davide; Lazarevic, Dejan; Provero, Paolo.

In: F1000Research, Vol. 5, 274, 2016.

Research output: Contribution to journalArticle

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