Chromatin and cell death

Research output: Contribution to journalArticlepeer-review

Abstract

HMGB1, a very mobile chromatin protein, leaks out from necrotic cells and signals to neighbouring cells that tissue damage has occurred. At least one receptor for extracellular HMGB1 exists, and signals to different cells to divide, migrate, activate inflammation or start an immune response. Remarkably, apoptotic chromatin binds HMGB1 irreversibly, thereby ensuring that it will not diffuse away to activate responses from neighbouring cells. Thus, dying cells use their own chromatin to signal how they have died. We argue that the nuclear events in apoptosis serve to control the molecular signals that dying cells send out.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalBBA - Gene Structure and Expression
Volume1677
Issue number1-3
DOIs
Publication statusPublished - Mar 15 2004

Keywords

  • Apoptosis
  • Chromatin
  • Histone
  • HMGB
  • Necrosis

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Structural Biology
  • Biophysics

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