Chromatin and transcriptional activity in early Xenopus development

Nicoletta Landsberger, Alan P. Wolffe

Research output: Contribution to journalArticlepeer-review

Abstract

Experiments with Xenopus oocytes and embryos have determined a direct biochemical relationship between chromatin structure and transcription. Nucleosomes within specific nucleoprotein architectures can either activate or repress transcription. Developmentally regulated changes in chromosomal composition direct the dominant repression of specific genes. Reconstruction of chromatin templates in vivo establishes that replication-coupled chromatin assembly both represses basal transcription and facilitates a full range of inducible gene activity. Chromatin structure emerges as a major contributory factor to the regulation of genes.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume6
Issue number4
Publication statusPublished - 1995

Keywords

  • Developmental control
  • Histone acetylation
  • HMGs
  • Linker histone
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology

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