Chromatin barcodes as biomarkers for melanoma

Emanuela Bastonini, Magdalena Jeznach, Megan Field, Katarzyna Juszczyk, Emily Corfield, Mehrnoush Dezfouli, Nurfilza Ahmat, Aimee Smith, Howard Womersley, Philip Jordan, Aroul Ramadass, Alexandre Akoulitchev, Colin R. Goding

Research output: Contribution to journalArticlepeer-review

Abstract

The major barrier to effective cancer therapy is the presence of genetic and phenotypic heterogeneity within cancer cell populations that provides a reservoir of therapeutically resistant cells. As the degree of heterogeneity present within tumours will be proportional to tumour burden, the development of rapid, robust, accurate and sensitive biomarkers for cancer progression that could detect clinically occult disease before substantial heterogeneity develops would provide a major therapeutic benefit. Here, we explore the application of chromatin conformation capture technology to generate a diagnostic epigenetic barcode for melanoma. The results indicate that binary states from chromatin conformations at 15 loci within five genes can be used to provide rapid, non-invasive multivariate test for the presence of melanoma using as little as 200 μl of patient blood.

Original languageEnglish
Pages (from-to)788-800
Number of pages13
JournalPigment Cell and Melanoma Research
Volume27
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Biomarker
  • Chromatin conformation capture
  • Epigentic
  • Melanoma

ASJC Scopus subject areas

  • Dermatology
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)

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