Chromatin is an essential substrate at which multiple signals are integrated to promote a perfectly choreographed expression of the genes involved in inflammatory transcriptional responses. Nuclear translocation of inflammatory transcription factors can be dissociated from activation of specific genes because of chromatin regulated mechanisms controlling their recruitment to selected cognate binding sites in a highly promoter specific manner. Control of chromatin remodeling and binding site accessibility provides an additional regulatory layer ultimately shaping and tuning the ensuing transcriptional program in a manner that integrates information on the strength, duration, and nature of the stimulus. It can be assumed that a similar integration of signals and mechanisms operates in the vast majority of stimulus induced transcriptional responses, and from this point of view inflammatory gene regulation may provide paradigms and models of wider applicability. Furthermore, it is anticipated that in the near future, the availability of detailed genome-wide chromatin maps describing nucleosome positions and their modifications in different basal and stimulated conditions, coupled with more accurate and complete information on transcription factor binding site affinities, would allow generating integrated and predictive models faithfully describing inducible transcriptional responses.
|Title of host publication||Handbook of Cell Signaling, 2/e|
|Number of pages||6|
|Publication status||Published - 2010|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)