Abstract
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
Original language | English |
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Pages (from-to) | 21-31 |
Number of pages | 11 |
Journal | Journal of Molecular and Cellular Cardiology |
Volume | 83 |
DOIs | |
Publication status | Published - Jun 1 2015 |
Keywords
- Aging
- Cardiovascular disease
- DNA methylation
- Histone methylation
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine