Abstract
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
| Original language | English |
|---|---|
| Pages (from-to) | 21-31 |
| Number of pages | 11 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 83 |
| DOIs | |
| Publication status | Published - Jun 1 2015 |
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Keywords
- Aging
- Cardiovascular disease
- DNA methylation
- Histone methylation
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Chromatin methylation and cardiovascular aging. / Illi, Barbara; Ciarapica, Roberta; Capogrossi, Maurizio C.
In: Journal of Molecular and Cellular Cardiology, Vol. 83, 01.06.2015, p. 21-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromatin methylation and cardiovascular aging
AU - Illi, Barbara
AU - Ciarapica, Roberta
AU - Capogrossi, Maurizio C.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
AB - DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
KW - Aging
KW - Cardiovascular disease
KW - DNA methylation
KW - Histone methylation
UR - http://www.scopus.com/inward/record.url?scp=84937973423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937973423&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2015.02.011
DO - 10.1016/j.yjmcc.2015.02.011
M3 - Article
C2 - 25724723
AN - SCOPUS:84937973423
VL - 83
SP - 21
EP - 31
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
ER -