Chromatin methylation and cardiovascular aging

Barbara Illi, Roberta Ciarapica, Maurizio C. Capogrossi

Research output: Contribution to journalArticle

Abstract

DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

Original languageEnglish
Pages (from-to)21-31
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Volume83
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Aging
  • Cardiovascular disease
  • DNA methylation
  • Histone methylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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