Abstract
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
| Original language | English |
|---|---|
| Pages (from-to) | 21-31 |
| Number of pages | 11 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 83 |
| DOIs | |
| Publication status | Published - Jun 1 2015 |
Keywords
- Aging
- Cardiovascular disease
- DNA methylation
- Histone methylation
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
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Cite this
Illi, B., Ciarapica, R., & Capogrossi, M. C. (2015). Chromatin methylation and cardiovascular aging. Journal of Molecular and Cellular Cardiology, 83, 21-31. https://doi.org/10.1016/j.yjmcc.2015.02.011