Chromatin methylation and cardiovascular aging

Barbara Illi; Roberta Ciarapica; Maurizio C. Capogrossi

doi:10.1016/j.yjmcc.2015.02.011

Chromatin methylation and cardiovascular aging

Barbara Illi, Roberta Ciarapica, Maurizio C. Capogrossi

Research output: Contribution to journal › Article › peer-review

Abstract

DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

Original language	English
Pages (from-to)	21-31
Number of pages	11
Journal	Journal of Molecular and Cellular Cardiology
Volume	83
DOIs	https://doi.org/10.1016/j.yjmcc.2015.02.011
Publication status	Published - Jun 1 2015

Keywords

Aging
Cardiovascular disease
DNA methylation
Histone methylation

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/j.yjmcc.2015.02.011

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title = "Chromatin methylation and cardiovascular aging",

abstract = "DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called {"}epigenetic drift{"}, in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).",

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AU - Ciarapica, Roberta

AU - Capogrossi, Maurizio C.

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N2 - DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

AB - DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

KW - Aging

KW - Cardiovascular disease

KW - DNA methylation

KW - Histone methylation

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JO - Journal of Molecular and Cellular Cardiology

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SN - 0022-2828

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Chromatin methylation and cardiovascular aging

Abstract

Keywords

ASJC Scopus subject areas

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