Chromatin methylation and cardiovascular aging

Barbara Illi, Roberta Ciarapica, Maurizio C. Capogrossi

Research output: Contribution to journalArticlepeer-review


DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

Original languageEnglish
Pages (from-to)21-31
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Publication statusPublished - Jun 1 2015


  • Aging
  • Cardiovascular disease
  • DNA methylation
  • Histone methylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine


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