Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes

F. A. Manzoli, N. M. Maraldi, L. Cocco, S. Capitani, A. Facchini

Research output: Contribution to journalArticle

Abstract

Certain phospholipids are associated with the nonhistone chromosomal proteins extracted from normal B and chronic lymphocytic leukemia lymphocytes. The ratio of phospholipids to nonhistone chromosomal proteins was constant with the different methods used for isolating nuclei and extracting the chromatin, although the various methods allowed a different recovery of total lipids from chromatin. Three phospholipids were extractable from the nonhistone protein fraction, but their respective ratios varied in chronic lymphocytic leukemia compared to normal b lymphocytes. The most significant variation concerns the reduction of sphingomyelin content in leukemic lymphocytes, since this phospholipid in vitro affects both DNA stability and transcription.

Original languageEnglish
Pages (from-to)843-849
Number of pages7
JournalCancer Research
Volume37
Issue number3
Publication statusPublished - 1977

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B-Cell Chronic Lymphocytic Leukemia
Chromatin
Phospholipids
Non Histone Chromosomal Proteins
Lymphocytes
Sphingomyelins
Lipids
DNA
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Manzoli, F. A., Maraldi, N. M., Cocco, L., Capitani, S., & Facchini, A. (1977). Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes. Cancer Research, 37(3), 843-849.

Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes. / Manzoli, F. A.; Maraldi, N. M.; Cocco, L.; Capitani, S.; Facchini, A.

In: Cancer Research, Vol. 37, No. 3, 1977, p. 843-849.

Research output: Contribution to journalArticle

Manzoli, FA, Maraldi, NM, Cocco, L, Capitani, S & Facchini, A 1977, 'Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes', Cancer Research, vol. 37, no. 3, pp. 843-849.
Manzoli FA, Maraldi NM, Cocco L, Capitani S, Facchini A. Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes. Cancer Research. 1977;37(3):843-849.
Manzoli, F. A. ; Maraldi, N. M. ; Cocco, L. ; Capitani, S. ; Facchini, A. / Chromatin phospholipids in normal and chronic lymphocytic leukemia lymphocytes. In: Cancer Research. 1977 ; Vol. 37, No. 3. pp. 843-849.
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