Chromatin structure, DNA methylation, and gene expression at sites of viral integration in human fibroblasts. Implications for chromosomal fragility

Alessandro De Ambrosis, Ida Casciano, Flavia Querzola, Giorgio Vidali, Massimo Romani

Research output: Contribution to journalArticle

Abstract

We analyzed the structural and functional properties of a chromosomal region in which a recombinant hybrid virus adenovirus 5/SV40 preferentially integrates. Our results demonstrated that the structure of the cellular targets for DNA and RNA viruses is very similar and that the cellular sequence flanking the integrated virus possesses, simultaneously, all the features postulated to be the molecular basis for chromosomal fragility.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume60
Issue number1
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Chromatin structure, DNA methylation, and gene expression at sites of viral integration in human fibroblasts. Implications for chromosomal fragility'. Together they form a unique fingerprint.

  • Cite this