Abstract
Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic terminals are a main source of CHGA but also myocardial cells produce it under stress conditions. After secretion, CHGA is cleaved into several biologically active fragments, including vasostatins and catestatin. CHGA and its proteolytic peptides exert a broad spectrum of activities on the cardiovascular system. They act on blood pressure by controlling the vascular tone and the cardiac inotropic and chronotropic function. CHGA revealed to be a sensitive marker of myocardial dysfunction, with a high predictive power of morbidity and mortality in heart failure and ischemic heart disease. In addition, CHGA has been involved in the control of sustained endothelial inflammation and has been shown to be a good marker of persistent vascular inflammation in rheumatologic disorders affecting vessels.
| Original language | English |
|---|---|
| Pages (from-to) | 409-414 |
| Number of pages | 6 |
| Journal | Journal of Hypertension |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
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Keywords
- catecholamines
- chromogranin A
- heart failure
- hypertension
- vasculitis
- vasostatin
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Chromogranin A : A novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems. / Di Comite, Gabriele; Morganti, Alberto.
In: Journal of Hypertension, Vol. 29, No. 3, 03.2011, p. 409-414.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromogranin A
T2 - A novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems
AU - Di Comite, Gabriele
AU - Morganti, Alberto
PY - 2011/3
Y1 - 2011/3
N2 - Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic terminals are a main source of CHGA but also myocardial cells produce it under stress conditions. After secretion, CHGA is cleaved into several biologically active fragments, including vasostatins and catestatin. CHGA and its proteolytic peptides exert a broad spectrum of activities on the cardiovascular system. They act on blood pressure by controlling the vascular tone and the cardiac inotropic and chronotropic function. CHGA revealed to be a sensitive marker of myocardial dysfunction, with a high predictive power of morbidity and mortality in heart failure and ischemic heart disease. In addition, CHGA has been involved in the control of sustained endothelial inflammation and has been shown to be a good marker of persistent vascular inflammation in rheumatologic disorders affecting vessels.
AB - Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic terminals are a main source of CHGA but also myocardial cells produce it under stress conditions. After secretion, CHGA is cleaved into several biologically active fragments, including vasostatins and catestatin. CHGA and its proteolytic peptides exert a broad spectrum of activities on the cardiovascular system. They act on blood pressure by controlling the vascular tone and the cardiac inotropic and chronotropic function. CHGA revealed to be a sensitive marker of myocardial dysfunction, with a high predictive power of morbidity and mortality in heart failure and ischemic heart disease. In addition, CHGA has been involved in the control of sustained endothelial inflammation and has been shown to be a good marker of persistent vascular inflammation in rheumatologic disorders affecting vessels.
KW - catecholamines
KW - chromogranin A
KW - heart failure
KW - hypertension
KW - vasculitis
KW - vasostatin
UR - http://www.scopus.com/inward/record.url?scp=79951680714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951680714&partnerID=8YFLogxK
U2 - 10.1097/HJH.0b013e328341a429
DO - 10.1097/HJH.0b013e328341a429
M3 - Article
C2 - 21178786
AN - SCOPUS:79951680714
VL - 29
SP - 409
EP - 414
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 3
ER -