Chromogranin A and other enteroendocrine markers in inflammatory bowel disease

Sara Massironi, Alessandra Zilli, Federica Cavalcoli, Dario Conte, Maddalena Peracchi

Research output: Contribution to journalArticlepeer-review


Changes in the distribution and products of enteroendocrine cells may play a role in immune activation and regulation of gut inflammation. This review aims at critically evaluating the main enteroendocrine markers in inflammatory bowel diseases (IBD). A narrative review was performed by searching inflammatory bowel diseases and enteroendocrine biomarkers in PubMed. Relevant modifications of some enteroendocrine markers, such as Chromogranin A, and their correlation with disease activity have been reported in patients with inflammatory bowel diseases. Even if data about neuroendocrine markers are sometimes contrasting, they may be potentially useful for the diagnosis and clinical management of these patients.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
Publication statusPublished - 2016


  • Chromogranin A
  • Crohn's disease
  • Enteroendocrine cell
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems


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