Chromogranin a and the endothelial barrier function

Research output: Contribution to journalArticle

Abstract

Chromogranin A (CgA) is an acidic glycoprotein belonging to a family of regulated secretory proteins stored in the dense core granules of many neuroendocrine cells and neurons. This protein is produced, in certain conditions also by cardiomyocytes, keratinocytes and granulocytes. Upon secretion CgA is released in the extracellular environment and then in circulation. Increased levels of circulating CgA have been detected in patients with cancer, heart failure, hypertension, atrophic gastritis, renal failure, giant cell artheritis, rheumatoid arthritis, sepsis and other inflammatory diseases. Endothelial cells, either those located in the close proximity of secretory cells or in distant tissues, may be exposed, therefore, to variable levels of CgA. In this review we discuss recent findings that implicate CgA and its fragments as a modulators of the physiology of endothelial cells in normal and in pathological conditions. In particular, we review data that suggest that CgA and its N-terminal fragment, called vasostatin-1, are important modulators of the endothelial barrier function and potent inhibitors of the endothelial cell activation caused by inflammatory and pro-angiogenic cytokines, with potential implications in angiogenesis, inflammation and cancer.

Original languageEnglish
Pages (from-to)4051-4058
Number of pages8
JournalCurrent Medicinal Chemistry
Volume19
Issue number24
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Angiogenesis
  • Cancer
  • Chromogranin A
  • Endothelial barrier function
  • Endothelial cell
  • Neuroendocrine tumors
  • NGR-TNF
  • TNF
  • Vascular leakage
  • Vasostatin-1
  • VE-cadherin
  • VEGF

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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