Chromogranin A in tumors: More than a marker for diagnosis and prognosis

Angelo Corti, Elisabetta Ferrero

Research output: Contribution to journalArticlepeer-review

Abstract

Chromogranin A (CgA), a protein stored in the secretory granules of many neuroendocrine cells and neurons, is believed to play intracellular and extracellular functions as a regulator of secretory granules biogenesis and as a precursor of various regulatory peptides of the endocrine and the metabolic systems. CgA is abnormally expressed by various neuroendocrine tumors and is released in high amounts in the blood stream. Detection of CgA in tumor tissues and in biological fluids has proven useful for tumor diagnosis and for monitoring tumor progression/regression after therapy. However, little is known on the effect of excessive production of CgA on tumor behavior. A growing body of evidence suggests that tumor-derived CgA is not only an important diagnostic and prognostic marker, but that it could also play a role in tumor/host interaction.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalCurrent Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Cell adhesion
  • Chromogranin A
  • Endothelial cells
  • Neuroendocrine tumor
  • Tumor necrosis factor
  • Tumor stroma
  • Vascular leakage

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

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