Chromogranin-reactive endocrine cells in argyrophilic carcinomas ('carcinoids') and normal tissue of the breast

G. Bussolati, P. Gugliotta, A. Sapino, V. Eusebi, R. V. Lloyd

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Breast carcinoma, either positive or negative with the Grimelius' silver procedure, benign fibroadenomas, duct papillomas, and areas of histologically normal breast tissue were tested immunocytochemically with the mouse monoclonal antibody LK2H10 directed against human chromogranin. This is regarded as a general stain for polypeptide-hormone-producing cells and tumors. In 3 of the 9 cases of argyrophilic carcinoma, but in none of 12 ductal infiltrating carcinomas, chromogranin-positive cells were found: the number of reactive cells was very low in 1 case, while in the other 2 carcinomas about 50% of the argyrophilic cells appeared stained. In areas of histologically normal breast tissue, rare argyrophilic chromogranin-positive cells were detected. This study is the first reported evidence concerning the presence of endocrinelike cells probably belonging to the diffuse neuroendocrine system in the normal mammary parenchyma. Our data are consistent with the endocrine nature of at least some of the breast argyrophilic carcinomas.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalAmerican Journal of Pathology
Volume120
Issue number2
Publication statusPublished - 1985

Fingerprint

Chromogranins
Endocrine Cells
Carcinoid Tumor
Breast
Carcinoma
Breast Neoplasms
Fibroadenoma
Ductal Carcinoma
Neurosecretory Systems
Peptide Hormones
Papilloma
Silver
Coloring Agents
Cell Count
Monoclonal Antibodies
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Chromogranin-reactive endocrine cells in argyrophilic carcinomas ('carcinoids') and normal tissue of the breast. / Bussolati, G.; Gugliotta, P.; Sapino, A.; Eusebi, V.; Lloyd, R. V.

In: American Journal of Pathology, Vol. 120, No. 2, 1985, p. 186-192.

Research output: Contribution to journalArticle

Bussolati, G. ; Gugliotta, P. ; Sapino, A. ; Eusebi, V. ; Lloyd, R. V. / Chromogranin-reactive endocrine cells in argyrophilic carcinomas ('carcinoids') and normal tissue of the breast. In: American Journal of Pathology. 1985 ; Vol. 120, No. 2. pp. 186-192.
@article{1797e4cac4cf42798d577edd190ea76f,
title = "Chromogranin-reactive endocrine cells in argyrophilic carcinomas ('carcinoids') and normal tissue of the breast",
abstract = "Breast carcinoma, either positive or negative with the Grimelius' silver procedure, benign fibroadenomas, duct papillomas, and areas of histologically normal breast tissue were tested immunocytochemically with the mouse monoclonal antibody LK2H10 directed against human chromogranin. This is regarded as a general stain for polypeptide-hormone-producing cells and tumors. In 3 of the 9 cases of argyrophilic carcinoma, but in none of 12 ductal infiltrating carcinomas, chromogranin-positive cells were found: the number of reactive cells was very low in 1 case, while in the other 2 carcinomas about 50{\%} of the argyrophilic cells appeared stained. In areas of histologically normal breast tissue, rare argyrophilic chromogranin-positive cells were detected. This study is the first reported evidence concerning the presence of endocrinelike cells probably belonging to the diffuse neuroendocrine system in the normal mammary parenchyma. Our data are consistent with the endocrine nature of at least some of the breast argyrophilic carcinomas.",
author = "G. Bussolati and P. Gugliotta and A. Sapino and V. Eusebi and Lloyd, {R. V.}",
year = "1985",
language = "English",
volume = "120",
pages = "186--192",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Chromogranin-reactive endocrine cells in argyrophilic carcinomas ('carcinoids') and normal tissue of the breast

AU - Bussolati, G.

AU - Gugliotta, P.

AU - Sapino, A.

AU - Eusebi, V.

AU - Lloyd, R. V.

PY - 1985

Y1 - 1985

N2 - Breast carcinoma, either positive or negative with the Grimelius' silver procedure, benign fibroadenomas, duct papillomas, and areas of histologically normal breast tissue were tested immunocytochemically with the mouse monoclonal antibody LK2H10 directed against human chromogranin. This is regarded as a general stain for polypeptide-hormone-producing cells and tumors. In 3 of the 9 cases of argyrophilic carcinoma, but in none of 12 ductal infiltrating carcinomas, chromogranin-positive cells were found: the number of reactive cells was very low in 1 case, while in the other 2 carcinomas about 50% of the argyrophilic cells appeared stained. In areas of histologically normal breast tissue, rare argyrophilic chromogranin-positive cells were detected. This study is the first reported evidence concerning the presence of endocrinelike cells probably belonging to the diffuse neuroendocrine system in the normal mammary parenchyma. Our data are consistent with the endocrine nature of at least some of the breast argyrophilic carcinomas.

AB - Breast carcinoma, either positive or negative with the Grimelius' silver procedure, benign fibroadenomas, duct papillomas, and areas of histologically normal breast tissue were tested immunocytochemically with the mouse monoclonal antibody LK2H10 directed against human chromogranin. This is regarded as a general stain for polypeptide-hormone-producing cells and tumors. In 3 of the 9 cases of argyrophilic carcinoma, but in none of 12 ductal infiltrating carcinomas, chromogranin-positive cells were found: the number of reactive cells was very low in 1 case, while in the other 2 carcinomas about 50% of the argyrophilic cells appeared stained. In areas of histologically normal breast tissue, rare argyrophilic chromogranin-positive cells were detected. This study is the first reported evidence concerning the presence of endocrinelike cells probably belonging to the diffuse neuroendocrine system in the normal mammary parenchyma. Our data are consistent with the endocrine nature of at least some of the breast argyrophilic carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=0022181967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022181967&partnerID=8YFLogxK

M3 - Article

C2 - 4025508

AN - SCOPUS:0022181967

VL - 120

SP - 186

EP - 192

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 2

ER -