Chromosomal aberrations and common fragile sites in neuroblastoma patients

P. Vernole, B. Tedeschi, C. Pianca, B. Nicoletti, R. Riccardi, G. Melino

Research output: Contribution to journalArticlepeer-review


We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Issue number4-6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Biochemistry


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