Chromosomal aberrations and common fragile sites in neuroblastoma patients

P. Vernole; B. Tedeschi; C. Pianca; B. Nicoletti; R. Riccardi; G. Melino

Chromosomal aberrations and common fragile sites in neuroblastoma patients

P. Vernole, B. Tedeschi, C. Pianca, B. Nicoletti, R. Riccardi, G. Melino

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.

Original language	English
Pages (from-to)	247-251
Number of pages	5
Journal	Clinical Chemistry and Enzymology Communications
Volume	2
Issue number	4-6
Publication status	Published - 1990

ASJC Scopus subject areas

Clinical Biochemistry

Access to Document

Fingerprint Dive into the research topics of 'Chromosomal aberrations and common fragile sites in neuroblastoma patients'. Together they form a unique fingerprint.

Cite this

@article{a549ea6d1edc46a080a15649cf0c1fef,

title = "Chromosomal aberrations and common fragile sites in neuroblastoma patients",

abstract = "We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.",

author = "P. Vernole and B. Tedeschi and C. Pianca and B. Nicoletti and R. Riccardi and G. Melino",

year = "1990",

language = "English",

volume = "2",

pages = "247--251",

journal = "Clinical Chemistry and Enzymology Communications",

issn = "0892-2187",

publisher = "Harwood Academic Publishers",

number = "4-6",

}

TY - JOUR

T1 - Chromosomal aberrations and common fragile sites in neuroblastoma patients

AU - Vernole, P.

AU - Tedeschi, B.

AU - Pianca, C.

AU - Nicoletti, B.

AU - Riccardi, R.

AU - Melino, G.

PY - 1990

Y1 - 1990

N2 - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.

AB - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.

UR - http://www.scopus.com/inward/record.url?scp=0025253438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025253438&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0025253438

VL - 2

SP - 247

EP - 251

JO - Clinical Chemistry and Enzymology Communications

JF - Clinical Chemistry and Enzymology Communications

SN - 0892-2187

IS - 4-6

ER -