Abstract
We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.
| Original language | English |
|---|---|
| Pages (from-to) | 247-251 |
| Number of pages | 5 |
| Journal | Clinical Chemistry and Enzymology Communications |
| Volume | 2 |
| Issue number | 4-6 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Chromosomal aberrations and common fragile sites in neuroblastoma patients. / Vernole, P.; Tedeschi, B.; Pianca, C.; Nicoletti, B.; Riccardi, R.; Melino, G.
In: Clinical Chemistry and Enzymology Communications, Vol. 2, No. 4-6, 1990, p. 247-251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromosomal aberrations and common fragile sites in neuroblastoma patients
AU - Vernole, P.
AU - Tedeschi, B.
AU - Pianca, C.
AU - Nicoletti, B.
AU - Riccardi, R.
AU - Melino, G.
PY - 1990
Y1 - 1990
N2 - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.
AB - We analyzed cytogenetically blood cells and bone marrow cells from 20 neuroblastoma patients. Chromosome common fragile sites were induced by aphidicolin in normal peripheral blood lymphocytes. All neuroblastoma patients showed a higher increase of aberrations after aphidicolin treatment as compared to that found in normal controls. In some cases it was possible to correlate the increase of the expression of a specific fragile site, 1p32, with deletions in the same area in bone marrow cells.
UR - http://www.scopus.com/inward/record.url?scp=0025253438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025253438&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0025253438
VL - 2
SP - 247
EP - 251
JO - Clinical Chemistry and Enzymology Communications
JF - Clinical Chemistry and Enzymology Communications
SN - 0892-2187
IS - 4-6
ER -