Chromosomal aberrations, sister chromatid exchanges and high frequency cells in young patients with neurofibromatosis 1 (NF1)

M. P. Bigatti, G. Ardito, L. Lamberti, S. Crovella, M. Collell, S. Giordanino, L. Benso

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and high frequency cells (HFCs) have been assessed in peripheral blood lymphocytes of 10 neurofibromatosis (NF1) patients and 10 healthy controls. In both groups, the spontaneous rates and the induced (bleomycin for CA and MMC for SCE) frequencies were analyzed. No differences between cells from NF1 patients and controls were observed with respect to spontaneous or bleomycin induced CA. Spontaneous or MMC induced SCE frequencies were also similar in NF1 patients and controls. HFCs, on the contrary, were statistically lower in NF1 patients.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalNeoplasma
Volume47
Issue number4
Publication statusPublished - 2000

Keywords

  • Bleomycin
  • Chromosomal aberrations
  • HFCs
  • Mytomycin C
  • NF1
  • SCE

ASJC Scopus subject areas

  • Cancer Research

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