Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning endocrine pancreatic tumors

Giovanna Floridia, Giulia Grilli, Marco Salvatore, Chiara Pescucci, Patrick S. Moore, Aldo Scarpa, Domenica Taruscio

Research output: Contribution to journalArticle

Abstract

We have used comparative genomic hybridization to investigate changes in DNA copy number in 20 nonfunctioning endocrine pancreatic tumors. The total number of regional DNA imbalances per tumor showed variation from case to case and high genetic heterogeneity was observed. From 1 to 22 chromosomal anomalies were detected in 13 of the 20 cases evaluated. Overall gains predominated over losses with a ratio of about 3.9:1 (58 gains/15 losses). The mean total number of regions displaying imbalances increased from 1.25 per tumor for benign tumors to 5.25 for malignant tumors, although statistical significance was not reached (P = 0.074).

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume156
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this