Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes

V. Romano; P. Bosco; M. Rocchi; G. Costa; R. H. Leube; W. W. Franke; G. Romeo

doi:10.1159/000132612

Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes

V. Romano, P. Bosco, M. Rocchi, G. Costa, R. H. Leube, W. W. Franke, G. Romeo

www.irccs.oasi.en.it

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Abstract

The chromosomal location of representative members of the type I and type II subfamilies of the cytokeratin multigene family was determined using specific cDNA probes in Southern blot hybridization with DNA from somatic cell hybrids. Our results show that the gene encoding human type II cytokeratin 4 resides on chromosome 12 and that encoding type I cytokeratin 15 is located on chromosome 17. The results indicate that cyto-keratinsare not concentrated in only one cluster. The possibility of the existence of separate type I and type II cytokeratin gene clusters is discussed.

Original language	English
Pages (from-to)	148-151
Number of pages	4
Journal	Cytogenetic and Genome Research
Volume	48
Issue number	3
DOIs	https://doi.org/10.1159/000132612
Publication status	Published - 1988

ASJC Scopus subject areas

Genetics
Molecular Biology
Genetics(clinical)
Cell Biology

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AU - Romano, V.

AU - Bosco, P.

AU - Rocchi, M.

AU - Costa, G.

AU - Leube, R. H.

AU - Franke, W. W.

AU - Romeo, G.

PY - 1988

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AB - The chromosomal location of representative members of the type I and type II subfamilies of the cytokeratin multigene family was determined using specific cDNA probes in Southern blot hybridization with DNA from somatic cell hybrids. Our results show that the gene encoding human type II cytokeratin 4 resides on chromosome 12 and that encoding type I cytokeratin 15 is located on chromosome 17. The results indicate that cyto-keratinsare not concentrated in only one cluster. The possibility of the existence of separate type I and type II cytokeratin gene clusters is discussed.

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