Chromosomal imbalances in pediatric Burkitt-like lymphoma and review of the literature in relation to other germinal center derived B-cell tumors

Annalisa Pezzolo, Roberta Cinti, Francesca Negri, Federica Parodi, Alberto Garaventa, Claudio Gambini, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

This study reports on the cytogenetic features of a novel case of pediatric Burkitt-like lymphoma (BLL), that adds to the three published. Four groups of cytogenetic abnormalities were detected in the present case: (1) imbalances shared by most germinal center (GC) derived B-cell tumors including BLL (+1q, -6q, -8p, +8q24 and +11); (2) imbalances already reported in adult but not in pediatric BLL cases and shared with most GC B-cell tumors (+7, -9p, -9q, +12q, -13q, +17, +19, -3 and -4); (3) imbalances already reported in pediatric but not in adult BLL cases and shared with some GC B-cell tumors (-2q); and (4) imbalances never described before in pediatric or adult BLL, but present in different GC B-cell tumors (-6p, -1p and -18q). In view of the paucity of pediatric BLL cases published, this report adds novel, relevant information on the molecular cytogenetic features of this rare tumor.

Original languageEnglish
Pages (from-to)2359-2364
Number of pages6
JournalLeukemia and Lymphoma
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Burkitt-like lymphoma
  • CGH
  • Chromosomal imbalances
  • FISH
  • Germinal center derived B-cell tumors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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