Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and Endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis

Valeria Tiranti, Elena Rossi, Adolf Ruiz-Carrillo, Giacomina Rossi, Mariano Rocchi, Stefano Didonato, Orsetta Zuffardi, Massimo Zeviani

Research output: Contribution to journalArticle

Abstract

By using a PCR-based screening of a somatic cell hybrid panel and FISH, we have assigned the loci of mitochondrial single-stranded DNA-binding protein (SSBP), mitochondrial transcription factor A (TCF6), and mitochondrial endonuclease G (ENDOG) genes to human chromosomes 7q34, 10q21, and 9q34.1, respectively. The products of these three genes are involved in fundamental aspects of mitochondrial biogenesis, such as replication and transcription of the mitochondrial genome. The chromosomal localization of these genes is important to testing whether the corresponding proteins may play a role in the etiopathogenesis of human disorders associated with qualitative or quantitative abnormalities of mitochondrial DNA.

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalGenomics
Volume25
Issue number2
DOIs
Publication statusPublished - Jan 20 1995

ASJC Scopus subject areas

  • Genetics

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