Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Ulrich O. Nagl; Martin Erdel; Andreas Schmarda; Marco Seri; Germar M. Pinggera; Martin Gschwentner; Christoph Duba; Luis J V Galietta; Peter Deetjen; Gerd Utermann; Markus Paulmichl

doi:10.1006/geno.1996.0651

Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Ulrich O. Nagl, Martin Erdel, Andreas Schmarda, Marco Seri, Germar M. Pinggera, Martin Gschwentner, Christoph Duba, Luis J V Galietta, Peter Deetjen, Gerd Utermann, Markus Paulmichl

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

Original language	English
Pages (from-to)	438-441
Number of pages	4
Journal	Genomics
Volume	38
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0651
Publication status	Published - Dec 15 1996

ASJC Scopus subject areas

Genetics

Access to Document

10.1006/geno.1996.0651

Cite this

Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln). / Nagl, Ulrich O.; Erdel, Martin; Schmarda, Andreas; Seri, Marco; Pinggera, Germar M.; Gschwentner, Martin; Duba, Christoph; Galietta, Luis J V; Deetjen, Peter; Utermann, Gerd; Paulmichl, Markus.

In: Genomics, Vol. 38, No. 3, 15.12.1996, p. 438-441.

Research output: Contribution to journal › Article › peer-review

Nagl, Ulrich O. ; Erdel, Martin ; Schmarda, Andreas ; Seri, Marco ; Pinggera, Germar M. ; Gschwentner, Martin ; Duba, Christoph ; Galietta, Luis J V ; Deetjen, Peter ; Utermann, Gerd ; Paulmichl, Markus. / Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln). In: Genomics. 1996 ; Vol. 38, No. 3. pp. 438-441.

@article{97935803ca0649d09d9650e07de681a5,

title = "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)",

abstract = "I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.",

author = "Nagl, {Ulrich O.} and Martin Erdel and Andreas Schmarda and Marco Seri and Pinggera, {Germar M.} and Martin Gschwentner and Christoph Duba and Galietta, {Luis J V} and Peter Deetjen and Gerd Utermann and Markus Paulmichl",

year = "1996",

month = dec,

day = "15",

doi = "10.1006/geno.1996.0651",

language = "English",

volume = "38",

pages = "438--441",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

AU - Nagl, Ulrich O.

AU - Erdel, Martin

AU - Schmarda, Andreas

AU - Seri, Marco

AU - Pinggera, Germar M.

AU - Gschwentner, Martin

AU - Duba, Christoph

AU - Galietta, Luis J V

AU - Deetjen, Peter

AU - Utermann, Gerd

AU - Paulmichl, Markus

PY - 1996/12/15

Y1 - 1996/12/15

N2 - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

AB - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

UR - http://www.scopus.com/inward/record.url?scp=0030589585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030589585&partnerID=8YFLogxK

U2 - 10.1006/geno.1996.0651

DO - 10.1006/geno.1996.0651

M3 - Article

C2 - 8975725

AN - SCOPUS:0030589585

VL - 38

SP - 438

EP - 441

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 3

ER -

Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this