Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Ulrich O. Nagl, Martin Erdel, Andreas Schmarda, Marco Seri, Germar M. Pinggera, Martin Gschwentner, Christoph Duba, Luis J V Galietta, Peter Deetjen, Gerd Utermann, Markus Paulmichl

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Abstract

I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalGenomics
Volume38
Issue number3
DOIs
Publication statusPublished - Dec 15 1996

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ASJC Scopus subject areas

  • Genetics

Cite this

Nagl, U. O., Erdel, M., Schmarda, A., Seri, M., Pinggera, G. M., Gschwentner, M., Duba, C., Galietta, L. J. V., Deetjen, P., Utermann, G., & Paulmichl, M. (1996). Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln). Genomics, 38(3), 438-441. https://doi.org/10.1006/geno.1996.0651