I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.
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