Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Ulrich O. Nagl; Martin Erdel; Andreas Schmarda; Marco Seri; Germar M. Pinggera; Martin Gschwentner; Christoph Duba; Luis J V Galietta; Peter Deetjen; Gerd Utermann; Markus Paulmichl

doi:10.1006/geno.1996.0651

Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Ulrich O. Nagl, Martin Erdel, Andreas Schmarda, Marco Seri, Germar M. Pinggera, Martin Gschwentner, Christoph Duba, Luis J V Galietta, Peter Deetjen, Gerd Utermann, Markus Paulmichl

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

Original language	English
Pages (from-to)	438-441
Number of pages	4
Journal	Genomics
Volume	38
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0651
Publication status	Published - Dec 15 1996

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0651

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title = "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)",

abstract = "I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.",

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doi = "10.1006/geno.1996.0651",

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T1 - Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

AU - Nagl, Ulrich O.

AU - Erdel, Martin

AU - Schmarda, Andreas

AU - Seri, Marco

AU - Pinggera, Germar M.

AU - Gschwentner, Martin

AU - Duba, Christoph

AU - Galietta, Luis J V

AU - Deetjen, Peter

AU - Utermann, Gerd

AU - Paulmichl, Markus

PY - 1996/12/15

Y1 - 1996/12/15

N2 - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

AB - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.

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Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)

Abstract

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