Abstract
I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 438-441 |
| Number of pages | 4 |
| Journal | Genomics |
| Volume | 38 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 15 1996 |
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ASJC Scopus subject areas
- Genetics
Cite this
Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln). / Nagl, Ulrich O.; Erdel, Martin; Schmarda, Andreas; Seri, Marco; Pinggera, Germar M.; Gschwentner, Martin; Duba, Christoph; Galietta, Luis J V; Deetjen, Peter; Utermann, Gerd; Paulmichl, Markus.
In: Genomics, Vol. 38, No. 3, 15.12.1996, p. 438-441.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel I(Cln)
AU - Nagl, Ulrich O.
AU - Erdel, Martin
AU - Schmarda, Andreas
AU - Seri, Marco
AU - Pinggera, Germar M.
AU - Gschwentner, Martin
AU - Duba, Christoph
AU - Galietta, Luis J V
AU - Deetjen, Peter
AU - Utermann, Gerd
AU - Paulmichl, Markus
PY - 1996/12/15
Y1 - 1996/12/15
N2 - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.
AB - I(Cln) is a cloned chloride channel paramount for regulatory volume decrease. Two different loci that carry the coding region for I(Cln) were identified in the human genome. By PCR strategies an intronless copy of the gene was located on chromosome 6 at position 6p12.1-6q13 (CLNS1B). By fluorescence in situ hybridization a copy carrying introns with a putative length of 19 kb was located at chromosome 11 on position 11q13.5-q14.1 (CLNS1A). The characterization and chromosomal localization of the I(Cln) gene offer the opportunity to study the regulatory sites of this gene in greater detail and could be helpful in establishing linkages between I(Cln) and potential human diseases.
UR - http://www.scopus.com/inward/record.url?scp=0030589585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030589585&partnerID=8YFLogxK
U2 - 10.1006/geno.1996.0651
DO - 10.1006/geno.1996.0651
M3 - Article
C2 - 8975725
AN - SCOPUS:0030589585
VL - 38
SP - 438
EP - 441
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -