Chromosome 17p deletion in human medulloblastoma: A missing checkpoint in the Hedgehog pathway

Enrico De Smaele, Lucia Di Marcotullio, Elisabetta Ferretti, Isabella Screpanti, Edoardo Alesse, Alberto Gulino

Research output: Contribution to journalArticle

Abstract

Although deregulation of Hedgehog signalling is considered to play a crucial oncogenic role and commonly occurrs in medulloblastoma, genetic lesions in components of this pathway are observed in a minority of cases. The recent identification of a novel putative tumor suppressor (RENKCTD11) on chromosome 17p13.2, a region most frequently lost in human medulloblastoma, highlights the role of allelic deletion of the gene in this brain malignancy, leading to the loss of growth inhibitory activity via suppression of Gil-dependent activation of Hedgehog target genes. The presence on 17p13 of another tumor suppressor gene (p53) whose inactivation cooperates with Hedgehog pathway for medulloblastoma formation, suggests that 17p deletion unveils haploinsufficiency conditions leading to abrogation of either direct and indirect checkpoints of Hedgehog signalling in cancer.

Original languageEnglish
Pages (from-to)1263-1266
Number of pages4
JournalCell Cycle
Volume3
Issue number10
Publication statusPublished - Oct 2004

    Fingerprint

Keywords

  • 17p deletion
  • Gli1
  • Hedgehog
  • Medulloblastoma
  • p53
  • RENKCTD11

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

De Smaele, E., Di Marcotullio, L., Ferretti, E., Screpanti, I., Alesse, E., & Gulino, A. (2004). Chromosome 17p deletion in human medulloblastoma: A missing checkpoint in the Hedgehog pathway. Cell Cycle, 3(10), 1263-1266.