Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

Simona Coco, Francesca Valdora, Stefano Bonassi, Paola Scaruffi, Sara Stigliani, André Oberthuer, Frank Berthold, Immacolata Andolfo, Tiziana Servidei, Riccardo Riccardi, Eleonora Basso, Achille Iolascon, Gian Paolo Tonini

Research output: Contribution to journalArticle

Abstract

Medulloblastoma (MB) is one of the most aggressive pediatric brain tumor. We report genome-wide pooled-analysis of classic MB variant of patients over 3 years of age at diagnosis. We combined array comparative genomic hybridization (aCGH) results from experimental analysis (31 cases) with two public databases (55 cases) in a final evaluation of 86 MBs. The most common chromosome structural aberrations were gains of 17q (45.3%), 1q (22.1%), and losses of 8p (15.1%), 10q (19.8%), 17p (37.2%), and 16q (16.3%). Isochromome (17q) was observed in 29.1% MBs. A significant association between poor patients survival and losses of 9q (p

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalOMICS A Journal of Integrative Biology
Volume15
Issue number5
DOIs
Publication statusPublished - May 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Molecular Medicine

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    Coco, S., Valdora, F., Bonassi, S., Scaruffi, P., Stigliani, S., Oberthuer, A., Berthold, F., Andolfo, I., Servidei, T., Riccardi, R., Basso, E., Iolascon, A., & Tonini, G. P. (2011). Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma. OMICS A Journal of Integrative Biology, 15(5), 273-280. https://doi.org/10.1089/omi.2010.0103