Chromosome aberrations can be often detected in tumors: some of them are specific of a given form, like the Ph' in chronic myeloid leukaemia; others are characteristic of a singular case of neoplasia (socalled 'marker' chromosomes); others are specific and difficult to classify. Sometimes it is possible, expecially during the blastic crisis of chronic myeloid leukemias or in neoplastic effusions, to follow the progressive evolution of chromosomal abnormalities (accordingly to 'stem line' and 'clonal evolution' theories). Not all the malignant tumors display detectable chromosomal aberrations and not all the chromosomal aberrations are indicative of malignancy. Nevertheless, the occurrence of characteristic chromosomal abnormalities in tumors, even if their genesis is not now fully understood, must play a great role in oncogenesis.
|Translated title of the contribution||Chromosome aberrations and neoplastic diseases|
|Number of pages||5|
|Publication status||Published - 1974|
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