Abstract
Chromosome aberrations can be often detected in tumors: some of them are specific of a given form, like the Ph' in chronic myeloid leukaemia; others are characteristic of a singular case of neoplasia (socalled 'marker' chromosomes); others are specific and difficult to classify. Sometimes it is possible, expecially during the blastic crisis of chronic myeloid leukemias or in neoplastic effusions, to follow the progressive evolution of chromosomal abnormalities (accordingly to 'stem line' and 'clonal evolution' theories). Not all the malignant tumors display detectable chromosomal aberrations and not all the chromosomal aberrations are indicative of malignancy. Nevertheless, the occurrence of characteristic chromosomal abnormalities in tumors, even if their genesis is not now fully understood, must play a great role in oncogenesis.
| Original language | Italian |
|---|---|
| Pages (from-to) | 83-87 |
| Number of pages | 5 |
| Journal | Progresso Medico |
| Volume | 30 |
| Issue number | 3 |
| Publication status | Published - 1974 |
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CROMOSOMI E NEOPLASIE. / Baserga, A.; Castoldi, G. L.; Dallapiccola, B.
In: Progresso Medico, Vol. 30, No. 3, 1974, p. 83-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CROMOSOMI E NEOPLASIE
AU - Baserga, A.
AU - Castoldi, G. L.
AU - Dallapiccola, B.
PY - 1974
Y1 - 1974
N2 - Chromosome aberrations can be often detected in tumors: some of them are specific of a given form, like the Ph' in chronic myeloid leukaemia; others are characteristic of a singular case of neoplasia (socalled 'marker' chromosomes); others are specific and difficult to classify. Sometimes it is possible, expecially during the blastic crisis of chronic myeloid leukemias or in neoplastic effusions, to follow the progressive evolution of chromosomal abnormalities (accordingly to 'stem line' and 'clonal evolution' theories). Not all the malignant tumors display detectable chromosomal aberrations and not all the chromosomal aberrations are indicative of malignancy. Nevertheless, the occurrence of characteristic chromosomal abnormalities in tumors, even if their genesis is not now fully understood, must play a great role in oncogenesis.
AB - Chromosome aberrations can be often detected in tumors: some of them are specific of a given form, like the Ph' in chronic myeloid leukaemia; others are characteristic of a singular case of neoplasia (socalled 'marker' chromosomes); others are specific and difficult to classify. Sometimes it is possible, expecially during the blastic crisis of chronic myeloid leukemias or in neoplastic effusions, to follow the progressive evolution of chromosomal abnormalities (accordingly to 'stem line' and 'clonal evolution' theories). Not all the malignant tumors display detectable chromosomal aberrations and not all the chromosomal aberrations are indicative of malignancy. Nevertheless, the occurrence of characteristic chromosomal abnormalities in tumors, even if their genesis is not now fully understood, must play a great role in oncogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016186601&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0016186601
VL - 30
SP - 83
EP - 87
JO - Progresso Medico
JF - Progresso Medico
SN - 0370-1514
IS - 3
ER -