Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: Pathogenetic and prognostic implications

Alfonso Zaccaria, Nicoletta Testoni, Anna Maria Valenti, Simona Luatti, Michela Tonelli, Giulia Marzocchi, Raffaella Cipriani, Carmen Baldazzi, Barbara Giannini, Monica Stacchini, Carla Gamberini, Fausto Castagnetti, Gianantonio Rosti, Annalisa Azzena, Francesco Cavazzini, Anna Maria Cianciulli, Alessia Dalsass, Emilio Donti, Emilia Giugliano, Alessandro GozzettiMaria Grazia Grimoldi, Sonia Ronconi, Alessandra Santoro, Francesco Spedicato, Lucia Zanatta, Michele Baccarani

Research output: Contribution to journalArticlepeer-review

Abstract

Additional chromosome abnormalities (ACAs) occur in less than 10% of cases at diagnosis of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). In some cases, on the basis of the persistence of the ACAs in Ph-negative cells after response to imatinib, a secondary origin of the Ph chromosome has been demonstrated. In this study, the possible prognostic value of this phenomenon was evaluated. Thirty-six Ph-positive CML patients were included in the study. In six patients, ACAs persisted after the disappearance of the Ph. A complete cytogenetic response (CCR) was obtained in five of these six patients, and five of six also had a high Sokal score. In all the other cases, ACAs disappeared together (in cases of response to therapy with imatinib) or persisted with the Ph (in cases of no response to imatinib). In the former cases, the primary origin of the Ph was demonstrated. CCR was obtained in 22 cases (17 with low to intermediate Sokal scores), while no response was observed in 8 patients (5 with a high Sokal score). Sokal score seems to maintain its prognostic value for patients in whom the Ph occurs as a primary event, but not in those in whom it occurs as a secondary one.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume199
Issue number2
DOIs
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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