TY - JOUR
T1 - Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia
T2 - Pathogenetic and prognostic implications
AU - Zaccaria, Alfonso
AU - Testoni, Nicoletta
AU - Valenti, Anna Maria
AU - Luatti, Simona
AU - Tonelli, Michela
AU - Marzocchi, Giulia
AU - Cipriani, Raffaella
AU - Baldazzi, Carmen
AU - Giannini, Barbara
AU - Stacchini, Monica
AU - Gamberini, Carla
AU - Castagnetti, Fausto
AU - Rosti, Gianantonio
AU - Azzena, Annalisa
AU - Cavazzini, Francesco
AU - Cianciulli, Anna Maria
AU - Dalsass, Alessia
AU - Donti, Emilio
AU - Giugliano, Emilia
AU - Gozzetti, Alessandro
AU - Grimoldi, Maria Grazia
AU - Ronconi, Sonia
AU - Santoro, Alessandra
AU - Spedicato, Francesco
AU - Zanatta, Lucia
AU - Baccarani, Michele
PY - 2010/6
Y1 - 2010/6
N2 - Additional chromosome abnormalities (ACAs) occur in less than 10% of cases at diagnosis of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). In some cases, on the basis of the persistence of the ACAs in Ph-negative cells after response to imatinib, a secondary origin of the Ph chromosome has been demonstrated. In this study, the possible prognostic value of this phenomenon was evaluated. Thirty-six Ph-positive CML patients were included in the study. In six patients, ACAs persisted after the disappearance of the Ph. A complete cytogenetic response (CCR) was obtained in five of these six patients, and five of six also had a high Sokal score. In all the other cases, ACAs disappeared together (in cases of response to therapy with imatinib) or persisted with the Ph (in cases of no response to imatinib). In the former cases, the primary origin of the Ph was demonstrated. CCR was obtained in 22 cases (17 with low to intermediate Sokal scores), while no response was observed in 8 patients (5 with a high Sokal score). Sokal score seems to maintain its prognostic value for patients in whom the Ph occurs as a primary event, but not in those in whom it occurs as a secondary one.
AB - Additional chromosome abnormalities (ACAs) occur in less than 10% of cases at diagnosis of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML). In some cases, on the basis of the persistence of the ACAs in Ph-negative cells after response to imatinib, a secondary origin of the Ph chromosome has been demonstrated. In this study, the possible prognostic value of this phenomenon was evaluated. Thirty-six Ph-positive CML patients were included in the study. In six patients, ACAs persisted after the disappearance of the Ph. A complete cytogenetic response (CCR) was obtained in five of these six patients, and five of six also had a high Sokal score. In all the other cases, ACAs disappeared together (in cases of response to therapy with imatinib) or persisted with the Ph (in cases of no response to imatinib). In the former cases, the primary origin of the Ph was demonstrated. CCR was obtained in 22 cases (17 with low to intermediate Sokal scores), while no response was observed in 8 patients (5 with a high Sokal score). Sokal score seems to maintain its prognostic value for patients in whom the Ph occurs as a primary event, but not in those in whom it occurs as a secondary one.
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U2 - 10.1016/j.cancergencyto.2010.02.003
DO - 10.1016/j.cancergencyto.2010.02.003
M3 - Article
C2 - 20471509
AN - SCOPUS:77952784266
VL - 199
SP - 76
EP - 80
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -