Chromosome abnormalities and fragile sites in human melanoma

Gabriella Sozzi, Monica Miozzo, Carla Calderone, Giuseppe Fossati, Marco A. Pierotti, Natale Cascinelli, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review


Chromosome analysis in short-term lines of three primary and seven metastatic malignant melanomas showed aneuploid karyotypes with recurrent abnormalities of chromosomes 1 (five cell lines), 6 (nine cell lines), and 7 (six cell lines). The breakpoints observed on the rearranged chromosomes frequently coincided with loci of known oncogenes and fragile sites. Two of the cell lines were analyzed after xenograft into nude mice and showed the presence of the same chromosomal changes observed in the parental cell lines, indicating the stability of the karyotype. A tendency toward an increased chromosomal fragility in peripheral blood lymphocytes was observed in five melanoma patients compared to ten normal individuals. However, there was no increased level of expression of specific fragile sites corresponding to the breakpoints observed in melanoma cells.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology


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