Chromosome mapping of murine susceptibility loci to liver carcinogenesis

Manuela Gariboldi, Giacomo Manenti, Federico Canzian, F. Stefania Falvella, Marco A. Pierotti, Giuseppe Della Porta, Giorgio Binelli, Tommaso A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J × C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalCancer Research
Volume53
Issue number2
Publication statusPublished - Jan 15 1993

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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