TY - JOUR
T1 - Chromosome mapping of murine susceptibility loci to liver carcinogenesis
AU - Gariboldi, Manuela
AU - Manenti, Giacomo
AU - Canzian, Federico
AU - Falvella, F. Stefania
AU - Pierotti, Marco A.
AU - Della Porta, Giuseppe
AU - Binelli, Giorgio
AU - Dragani, Tommaso A.
PY - 1993/1/15
Y1 - 1993/1/15
N2 - The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J × C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes.
AB - The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J × C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes.
UR - http://www.scopus.com/inward/record.url?scp=0027500318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027500318&partnerID=8YFLogxK
M3 - Article
C2 - 8417808
AN - SCOPUS:0027500318
VL - 53
SP - 209
EP - 211
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 2
ER -