Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study

Alfonso Zaccaria; Gianantonio Rosti; Nicoletta Testoni; Giuliana Alimena; William Arcese; Giuseppe Bandini; Marc Boogaerts; Felix Carbonell; Augustin Ferrant; Alberta Filippetti; Francesco Frassoni; Gösta Gahrton; Oskar A. Haas; Antonio Iacone; Cristina Mecucci; Jean Louis Michaux; Giandomenico Palka; Giuseppe Papa; Christine Pollak; Antonella Rosetti; Paolo Ricci; Thomas Schmeizer; Mario Sessarego; Stefania Valenti; Herman Van den Berghe; Sante Tura

doi:10.1016/0165-4608(87)90128-2

Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study

Alfonso Zaccaria, Gianantonio Rosti, Nicoletta Testoni, Giuliana Alimena, William Arcese, Giuseppe Bandini, Marc Boogaerts, Felix Carbonell, Augustin Ferrant, Alberta Filippetti, Francesco Frassoni, Gösta Gahrton, Oskar A. Haas, Antonio Iacone, Cristina Mecucci, Jean Louis Michaux, Giandomenico Palka, Giuseppe Papa, Christine Pollak, Antonella RosettiPaolo Ricci, Thomas Schmeizer, Mario Sessarego, Stefania Valenti, Herman Van den Berghe, Sante Tura

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.

Original language	English
Pages (from-to)	5-13
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(87)90128-2
Publication status	Published - 1987

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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10.1016/0165-4608(87)90128-2

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Zaccaria, A., Rosti, G., Testoni, N., Alimena, G., Arcese, W., Bandini, G., Boogaerts, M., Carbonell, F., Ferrant, A., Filippetti, A., Frassoni, F., Gahrton, G., Haas, O. A., Iacone, A., Mecucci, C., Michaux, J. L., Palka, G., Papa, G., Pollak, C., ... Tura, S. (1987). Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study. Cancer Genetics and Cytogenetics, 26(1), 5-13. https://doi.org/10.1016/0165-4608(87)90128-2

Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study. / Zaccaria, Alfonso; Rosti, Gianantonio; Testoni, Nicoletta; Alimena, Giuliana; Arcese, William; Bandini, Giuseppe; Boogaerts, Marc; Carbonell, Felix; Ferrant, Augustin; Filippetti, Alberta; Frassoni, Francesco; Gahrton, Gösta; Haas, Oskar A.; Iacone, Antonio; Mecucci, Cristina; Michaux, Jean Louis; Palka, Giandomenico; Papa, Giuseppe; Pollak, Christine; Rosetti, Antonella; Ricci, Paolo; Schmeizer, Thomas; Sessarego, Mario; Valenti, Stefania; Van den Berghe, Herman; Tura, Sante.

In: Cancer Genetics and Cytogenetics, Vol. 26, No. 1, 1987, p. 5-13.

Research output: Contribution to journal › Article › peer-review

Zaccaria, A, Rosti, G, Testoni, N, Alimena, G, Arcese, W, Bandini, G, Boogaerts, M, Carbonell, F, Ferrant, A, Filippetti, A, Frassoni, F, Gahrton, G, Haas, OA, Iacone, A, Mecucci, C, Michaux, JL, Palka, G, Papa, G, Pollak, C, Rosetti, A, Ricci, P, Schmeizer, T, Sessarego, M, Valenti, S, Van den Berghe, H & Tura, S 1987, 'Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study', Cancer Genetics and Cytogenetics, vol. 26, no. 1, pp. 5-13. https://doi.org/10.1016/0165-4608(87)90128-2

Zaccaria, Alfonso ; Rosti, Gianantonio ; Testoni, Nicoletta ; Alimena, Giuliana ; Arcese, William ; Bandini, Giuseppe ; Boogaerts, Marc ; Carbonell, Felix ; Ferrant, Augustin ; Filippetti, Alberta ; Frassoni, Francesco ; Gahrton, Gösta ; Haas, Oskar A. ; Iacone, Antonio ; Mecucci, Cristina ; Michaux, Jean Louis ; Palka, Giandomenico ; Papa, Giuseppe ; Pollak, Christine ; Rosetti, Antonella ; Ricci, Paolo ; Schmeizer, Thomas ; Sessarego, Mario ; Valenti, Stefania ; Van den Berghe, Herman ; Tura, Sante. / Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study. In: Cancer Genetics and Cytogenetics. 1987 ; Vol. 26, No. 1. pp. 5-13.

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abstract = "The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.",

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AU - Alimena, Giuliana

AU - Arcese, William

AU - Bandini, Giuseppe

AU - Boogaerts, Marc

AU - Carbonell, Felix

AU - Ferrant, Augustin

AU - Filippetti, Alberta

AU - Frassoni, Francesco

AU - Gahrton, Gösta

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AU - Pollak, Christine

AU - Rosetti, Antonella

AU - Ricci, Paolo

AU - Schmeizer, Thomas

AU - Sessarego, Mario

AU - Valenti, Stefania

AU - Van den Berghe, Herman

AU - Tura, Sante

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Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study

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