Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation-Results of a European cooperative study

Alfonso Zaccaria, Gianantonio Rosti, Nicoletta Testoni, Giuliana Alimena, William Arcese, Giuseppe Bandini, Marc Boogaerts, Felix Carbonell, Augustin Ferrant, Alberta Filippetti, Francesco Frassoni, Gösta Gahrton, Oskar A. Haas, Antonio Iacone, Cristina Mecucci, Jean Louis Michaux, Giandomenico Palka, Giuseppe Papa, Christine Pollak, Antonella RosettiPaolo Ricci, Thomas Schmeizer, Mario Sessarego, Stefania Valenti, Herman Van den Berghe, Sante Tura

Research output: Contribution to journalArticlepeer-review

Abstract

The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume26
Issue number1
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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